Evidence map›Paper›PMID 39818957›Full record

ArticleAntimicrobial agents and chemotherapy2025

Emergence of antibiotic-specific

Elizabeth A Wynn, Christian Dide-Agossou, Reem Al Mubarak, Karen Rossmassler, Victoria Ektnitphong, Allison A Bauman, Lisa M Massoudi, Martin I Voskuil, Gregory T Robertson, Camille M Moore and 1 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Adaptive immunity shapes baseline physiology ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Deconvoluting drug interactions usingAntimicrobial agents and chemotherapy · 2025
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Elizabeth A WynnRocky Mountain Regional VA Medical Center, Aurora, Colorado, USA.ORCID 0000-0002-5857-4483
Christian Dide-AgossouRocky Mountain Regional VA Medical Center, Aurora, Colorado, USA.ORCID 0000-0001-9854-1785
Reem Al MubarakRocky Mountain Regional VA Medical Center, Aurora, Colorado, USA.
Karen RossmasslerRocky Mountain Regional VA Medical Center, Aurora, Colorado, USA.
Victoria EktnitphongMycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Allison A BaumanMycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Lisa M MassoudiMycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Martin I VoskuilConsortium for Applied Microbial Metrics, Aurora, Colorado, USA.
Gregory T RobertsonConsortium for Applied Microbial Metrics, Aurora, Colorado, USA.ORCID 0000-0001-7157-4034
Camille M Moore *Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, USA.
Nicholas D Walter *Rocky Mountain Regional VA Medical Center, Aurora, Colorado, USA.ORCID 0000-0003-0126-1993

Funding

Preclinical Design and Clinical Translation of TB Regimens (PReDicTR) ConsortiumUM1AI179699 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kelly E. Dooley, ERIC L NUERMBERGER · 2024 to 2026
$22.2M
Sputum Transcriptomic Expression Profiling in Study 31: Express 31R01AI127300 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DAVIS, JOHN LUCIAN, NAHID, PAYAM · 2017 to 2022
$6.2M
Bill and Melinda Gates Foundation (GF) OPP1170003BLRD VA I01 BX004527Gates Foundation INV-009105HHS | National Institutes of Health (NIH) 1R01AI127300-01A1, 1UM1AI179699-01NIAID NIH HHS R01 AI127300NIAID NIH HHS UM1 AI179699U.S. Department of Veterans Affairs (VA) 1I01BX004527-01A1
6 · The paper itself

Abstract

A major challenge in tuberculosis (TB) therapeutics is that antibiotic exposure leads to changes in the physiology of

Indexed as

Anti-Bacterial AgentsAntitubercular AgentsMycobacterium tuberculosisTuberculosisAnimalsDiarylquinolinesDisease Models, AnimalEthambutolFemaleIsoniazidMiceMice, Inbred BALB CPhenotypePyrazinamideRifampinStreptomycinAnti-Bacterial AgentsAntitubercular AgentsbedaquilineDiarylquinolinesEthambutolIsoniazidPyrazinamideRifampinStreptomycinantibiotic exposureantibiotic resistanceM. tuberculosisRNA-sequencing

Identifiers

PMID39818957
PMCPMC11823617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.