Evidence map›Paper›PMID 39818729›Full record

ArticleACS nano2025

Bacterial Nanovesicles as Interkingdom Signaling Moieties Mediating Pain Hypersensitivity.

Sameh Almousa, Susy Kim, Ashish Kumar, Yixin Su, Sangeeta Singh, Shalini Mishra, Miriam M Fonseca, Hilal A Rather, E Alfonso Romero-Sandoval, Fang-Chi Hsu and 4 more

Abstract read
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Extracellular vesicles decoying across host immunity.Journal of leukocyte biology · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sameh AlmousaDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Susy KimDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Ashish KumarDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Yixin SuDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Sangeeta SinghDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Shalini MishraDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Miriam M FonsecaDepartment of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Hilal A RatherDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
E Alfonso Romero-SandovalDepartment of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Fang-Chi HsuDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.
Rakesh SinghInstitute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Hariom YadavUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, Florida 33612, United States.
Santosh MishraComparative Pain Research and Education Center, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, United States.
Gagan DeepDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, United States.ORCID 0000-0003-4445-8796

Funding

Exosome Mediated Alterations in Cellular Metabolism in the Pathogenesis and Progression of Alzheimer's DiseaseR01AG061805 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MOLINA, ANTHONY J · 2018 to 2022
$3.5M
Multi-Ethnic Study of Atherosclerosis- Cellular Exosomes in Neurodegeneration and Dementia (MESA-CEND)RF1AG068629 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEEP, GAGAN, HUGHES, TIMOTHY M. · 2021 to 2022
$2.4M
Endoplasmic Reticulum Stress Responses in PainR01NS114653 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOADA, MARIO DANILO, ROMERO-SANDOVAL, E. ALFONSO · 2020 to 2024
$2.0M
A unique exosome-based approach to identify novel biomarkers for Alzheimer's diseaseR21AG075611 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEEP, GAGAN · 2022 to 2022
$426k
NIA NIH HHS R01 AG061805NIA NIH HHS R21 AG075611NIA NIH HHS RF1 AG068629NINDS NIH HHS R01 NS114653
6 · The paper itself

Abstract

Gut dysbiosis contributes to multiple pathologies, yet the mechanisms of the gut microbiota-mediated influence on systemic and distant responses remain largely elusive. This study aimed to identify the role of nanosized bacterial extracellular vesicles (bEVs) in mediating allodynia, i.e., pain hypersensitivity, in a diet-induced obesity (DIO) gut dysbiosis model. bEVs were enriched from the feces of lean (bEV

Indexed as

Extracellular VesiclesHyperalgesiaNanoparticlesAnimalsDysbiosisGastrointestinal MicrobiomeInflammationMaleMiceMice, Inbred C57BLMice, KnockoutObesitySignal Transductionbacterial extracellular vesiclesdysbiosisgut microbiomeinflammationpain

Identifiers

PMID39818729
PMCPMC13198181

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.