ArticleBiological psychiatry2025
Sex Differences in the Striatal Contributions to Longitudinal Fine Motor Development in Autistic Children.
Article in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review of Autism in Women: Invisibilised Profiles and Gender Bias.Revista de neurologia · 2026Pooled it
- Multimodal predictors of spoken vocabulary development in autism: the role of early childhood brain and behavior.Translational psychiatry · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundFine motor challenges are prevalent in autistic populations. However, little is known about their neurobiological underpinnings or how their related neural mechanisms are influenced by sex. The dorsal striatum, which comprises the caudate nucleus and putamen, is associated with motor learning and control and may hold critical information. We investigated how autism diagnosis and sex assigned at birth influence associations between the dorsal striatum and fine motor development in autistic and nonautistic children.
methodsWe used multimodal assessment of striatal structures (volume and corticostriatal white matter microstructure) and longitudinal assessment of fine motor skills, first at approximately 3 years of age (time 1) and again 2 to 3 years later (follow-up). Fine motor and magnetic resonance imaging (T1 and diffusion) data were collected at time 1 from 356 children (234 autistic; 128 girls) and at follow-up from 195 children (113 autistic; 76 girls).
resultsAt time 1, associations among fine motor skills, putamen volume, and sensorimotor-striatal fractional anisotropy (sensorimotor-affiliated dorsal striatal structures) were different in autistic boys compared with autistic girls and were not significant for nonautistic children. Further, time 1 sensorimotor-striatal and prefrontal-striatal microstructure predicted fine motor development for autistic girls but not boys.
conclusionsSensorimotor-affiliated dorsal striatum structures may contribute to concurrent motor ability and predict fine motor improvement during critical windows of development in a sex-specific and diagnosis-dependent way. Moreover, the dorsal striatum may play a key role in the distinct neural mechanisms underlying motor challenges in autistic boys and girls.
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