Evidence map›Paper›PMID 39818205›Full record

ArticleCell host & microbe2025

Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning.

Gorka Lasso, Michael Grodus, Estefania Valencia, Veronica DeJesus, Eliza Liang, Isabel Delwel, Rob H Bortz, Dmitry Lupyan, Hanna Y Ehrlich, Adrian A Castellanos and 34 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Spatial risks of Orthoebolavirus spillover vary based on outbreak type.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Gorka LassoDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA. Electronic address: gorka.lasso@gmail.com.
Michael GrodusCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Estefania ValenciaDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Veronica DeJesusDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Eliza LiangCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Isabel DelwelDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Rob H BortzDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
Dmitry LupyanSchrödinger Inc., Cambridge, MA 02142, USA.
Hanna Y EhrlichOne Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Adrian A CastellanosCary Institute of Ecosystem Studies, Millbrook, NY 12545, USA.
Andrea GazzoDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Heather L WellsDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Supaporn WacharapluesadeeThai Red Cross Emerging Infectious Diseases Clinical Center, King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
Alexandre Tremeau-BravardOne Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Janine F R SeetahalDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66502, USA.
Tom HughesConservation Medicine, 47000 Sungai Buloh, Selangor, Malaysia; EcoHealth Alliance, New York, NY 10018, USA.
Jimmy LeeConservation Medicine, 47000 Sungai Buloh, Selangor, Malaysia; EcoHealth Alliance, New York, NY 10018, USA.
Mei-Ho LeeConservation Medicine, 47000 Sungai Buloh, Selangor, Malaysia; EcoHealth Alliance, New York, NY 10018, USA.
Anna R SjodinDepartment of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA.
Marike GeldenhuysCentre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria 0001, South Africa.
Marinda MortlockCentre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria 0001, South Africa.
Isamara Navarrete-MaciasDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Kirsten GilardiOne Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Michael R WilligDepartment of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA; Center for Environmental Sciences and Engineering, Institute of the Environment, University of Connecticut, Storrs, CT 06269, USA.
Alessandra F D NavaFundação Oswaldo Cruz-Fiocruz, Instituto Leônidas & Maria Deane, Laboratório de Ecologia de Doenças Transmissíveis na Amazônia - EDTA, Manaus 69.057-070, AM, Brazil.
Elisabeth H LohDivision of Natural Sciences and Mathematics, Transylvania University, Lexington, KY 40508, USA.
Makda AsratDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Tierra Smiley-EvansOne Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Walter S MagesaCollege of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, P.O. Box 3021, Morogoro, Tanzania.
Sijali ZikankubaCollege of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, P.O. Box 3021, Morogoro, Tanzania.
David WolkingOne Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Gerardo SuzánLaboratorio de Ecología de Enfermedades y Una Salud, Departamento de Etología, Fauna Silvestre y Animales de Laboratorio, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.
Rafael Ojeda-FloresLaboratorio de Ecología de Enfermedades y Una Salud, Departamento de Etología, Fauna Silvestre y Animales de Laboratorio, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.
Christine V F CarringtonDepartment of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Republic of Trinidad and Tobago.
Ariful IslamGulbali Research Institute, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.
Jonathan H EpsteinEcoHealth Alliance, New York, NY 10018, USA.
Wanda MarkotterCentre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria 0001, South Africa.
Christine K JohnsonOne Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Tracey GoldsteinOne Health Institute, Colorado State University, Fort Collins, CO 80523, USA.
Barbara A HanCary Institute of Ecosystem Studies, Millbrook, NY 12545, USA.
Jonna A K MazetOne Health Institute, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Rohit K JangraDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA; Center for Applied Immunology and Pathological Processes, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA; Center of Excellence for Emerging Viral Threats, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA. Electronic address: rohit.jangra@lsuhs.edu.
Kartik ChandranDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA. Electronic address: kartik.chandran@einsteinmed.edu.
Simon J AnthonyDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. Electronic address: sjanthony@ucdavis.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Project 4-Tracking cytomegalovirus-primed long-lived NK cells in salivary glandP20GM134974 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ANDREW D YUROCHKO · 2021 to 2026
$15.0M
Coordinating Research on Emerging Arboviral Threats Encompassing the Neotropics II (CREATE-NEO II)U01AI151807 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Kathryn Alyce Hanley, MAURICIO Lacerda NOGUEIRA · 2020 to 2026
$9.8M
Mechanism of receptor-mediated entry and infection by filovirusesR01AI101436 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHANDRAN, KARTIK · 2012 to 2016
$4.0M
Viral and host determinants of susceptibility of diverse hantavirusesR21AI156482 · NIAID · LOUISIANA STATE UNIV HSC SHREVEPORT · PI JANGRA, ROHIT K · 2021 to 2022
$452k
NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI101436NIAID NIH HHS R21 AI156482NIAID NIH HHS U01 AI151807NIGMS NIH HHS P20 GM134974
6 · The paper itself

Abstract

Evidence suggests that bats are important hosts of filoviruses, yet the specific species involved remain largely unidentified. Niemann-Pick C1 (NPC1) is an essential entry receptor, with amino acid variations influencing viral susceptibility and species-specific tropism. Herein, we conducted combinatorial binding studies with seven filovirus glycoproteins (GPs) and NPC1 orthologs from 81 bat species. We found that GP-NPC1 binding correlated poorly with phylogeny. By integrating binding assays with machine learning, we identified genetic factors influencing virus-receptor-binding and predicted GP-NPC1-binding avidity for additional filoviruses and bats. Moreover, combining receptor-binding avidities with bat geographic distribution and the locations of previous Ebola outbreaks allowed us to rank bats by their potential as Ebola virus hosts. This study represents a comprehensive investigation of filovirus-receptor binding in bats (1,484 GP-NPC1 pairs, 11 filoviruses, and 135 bats) and describes a multidisciplinary approach to predict susceptible species and guide filovirus host surveillance.

Indexed as

ChiropteraFiloviridaeFiloviridae InfectionsMachine LearningReceptors, VirusAnimalsEbolavirusGlycoproteinsHemorrhagic Fever, EbolaHumansNiemann-Pick C1 ProteinPhylogenyProtein BindingGlycoproteinsNiemann-Pick C1 ProteinReceptors, Virusbatbinding avidityfilovirusglycoproteinhostmachine learningNPC1protein-protein interactionsusceptibilityvirus

Identifiers

PMID39818205
PMCPMC11825280

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.