Evidence map›Paper›PMID 39817813›Full record

ArticleJournal of medicinal chemistry2025

Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease.

Ravi Kumar Akula, Haifa El Kilani, Alina Metzen, Judith Röske, Kaixuan Zhang, Matthias Göhl, Nanaji Arisetti, Graham P Marsh, Hannah J Maple, Mark S Cooper and 6 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ravi Kumar AkulaDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany.
Haifa El KilaniInstitute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany.
Alina MetzenDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany.
Judith RöskeInstitute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany.
Kaixuan ZhangInstitute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany.
Matthias GöhlDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany.
Nanaji ArisettiDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany.
Graham P MarshBio-Techne (Tocris), Bristol BS11 9QD, U.K.ORCID 0000-0003-0375-5145
Hannah J MapleBio-Techne (Tocris), Bristol BS11 9QD, U.K.ORCID 0000-0001-5050-0562
Mark S CooperBio-Techne (Tocris), Bristol BS11 9QD, U.K.
Burhan KaradoganBio-Techne (Tocris), Bristol BS11 9QD, U.K.
Dirk JochmansDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven 3000, Belgium.ORCID 0000-0002-9265-6028
Johan NeytsDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven 3000, Belgium.
Katharina RoxDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany.ORCID 0000-0002-8020-1384
Rolf HilgenfeldInstitute of Molecular Medicine, University of Lübeck, Ratzeburger Allee 160, Lübeck 23562, Germany.
Mark BrönstrupDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig 38124, Germany.ORCID 0000-0002-8971-7045

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main protease M

Indexed as

AmidesAntiviral AgentsCoronavirus 3C ProteasesPyridonesSARS-CoV-2COVID-19 Drug TreatmentHumansProtease InhibitorsStructure-Activity Relationship3C-like proteinase, SARS-CoV-2AmidesAntiviral AgentsCoronavirus 3C ProteasesProtease InhibitorsPyridones

Identifiers

PMID39817813
PMCPMC11831675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.