Observational studyJournal of the American Heart Association2025
Prognostic Value of D-Dimer in Acute Type A Aortic Dissection and Intramural Hematoma: Observations from the Acute Aortic Syndrome Group of the Registry of Acute Non-Traumatic Chest Pain in China.
Observational study in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Predictive Value of D-Dimer to Albumin Ratio for Outcome in Acute Type A Aortic Dissection Patients.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Diagnostic value of a combined model for acute aortic syndrome based on internal migration of calcification on non-contrast computed tomography.Journal of thoracic disease · 2026Article
- Machine learning-based prediction of postoperative continuous renal replacement therapy initiation after open thoracoabdominal aortic repair.BMC nephrology · 2026Article
- Article
- De Ritis Ratio as an Independent Predictor of In-Hospital Mortality in Surgically Treated Acute Aortic Dissection.Journal of clinical medicine · 2026Article
- Neutrophil-to-albumin ratio predicts 30-day mortality in acute aortic dissection: a retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Development and validation of a risk prediction model for postoperative pneumonia in elderly non-cardiac surgery patients: a retrospective cohort study.Scientific reports · 2025Article
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Abstract
backgroundAcute type A aortic dissection (AAD) and acute type A intramural hematoma (AIMH) are life-threatening conditions with high mortality rates, and prognostic indicators are critical for guiding urgent treatment decisions. We assessed the prognostic significance of admission D-dimer levels in patients with AAD and AIMH. METHODS AND
resultsThe prospective, multicenter, observational study in China recruited participants from 2013 to 2019. Patients with AAD and AIMH were respectively categorized into quartiles based on admission D-dimer levels. Cox regression analysis was used to assess the association between D-dimer levels and mortality. A total of 3132 patients with AAD (mean age: 50.63 years [SD, 12.56]) and 353 patients with AIMH (mean age: 59.63 years [SD, 11.00]) were included. In patients with AAD, overall mortality rates increased across D-dimer quartiles: 13.7% (Q1, ≤0.72 mg/L), 16.7% (Q2, 0.72-1.91 mg/L), 22.8% (Q3, 1.91-4.21 mg/L), and 28.5% (Q4, 4.21-20.00 mg/L). In patients with AIMH, mortality rates by quartile were 3.4% (Q1, ≤0.51 mg/L), 5.7% (Q2, 0.51-1.25 mg/L), 4.6% (Q3, 1.25-3.44 mg/L), and 10.2% (Q4, 3.44-20.00 mg/L). After adjusting for confounders, D-dimer was an independent predictor of overall mortality (hazard ratio [HR], 1.42 [95% CI, 1.11-1.80]) and in-hospital mortality (HR, 1.47 [95% CI, 1.13-1.92]) in patients with AAD. D-dimer levels were not significantly associated with the overall (HR, 2.61 [95% CI, 0.70-9.73]) or in-hospital mortality (HR, 1.78 [95% CI, 0.44-7.24]) of patients with AIMH by multivariable adjustment.
conclusionsElevated admission D-dimer levels are independently associated with higher mortality in patients with AAD but are not significantly associated with prognosis in patients with AIMH. Our findings suggest that D-dimer may serve as a useful prognostic marker in patients with AAD. REGISTRATION: www.chictr.org.cn. Unique identifier: ChiCTR230006854.
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