Evidence map›Paper›PMID 39817553›Full record

ArticleJournal of the American Heart Association2025

Janus Kinase 2/Signal Transducer and Activator of Transcription 3/Cyclooxygenase 2 Signaling Pathway Mediates the Effect of Central Angiotensin II on the Elevation of Rostral Ventrolateral Medulla Prostaglandin E

Jie-Fu Fan, Xing Tan, Wen Wang, Ji-Kui Li, Yu-Chen Xiao, Wei-Zhong Wang, Yang-Kai Wang

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. The sympathetic nervous system in the pathophysiology of hypertension: Mechanistic insights and therapeutic implications.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jie-Fu FanNaval Medical Center of PLA Naval Medical University (Second Military Medical University) Shanghai China.
Xing TanNaval Medical Center of PLA Naval Medical University (Second Military Medical University) Shanghai China.ORCID 0000-0002-1090-0438
Wen WangNaval Medical Center of PLA Naval Medical University (Second Military Medical University) Shanghai China.
Ji-Kui LiNaval Medical Center of PLA Naval Medical University (Second Military Medical University) Shanghai China.
Yu-Chen XiaoNaval Medical Center of PLA Naval Medical University (Second Military Medical University) Shanghai China.
Wei-Zhong WangNaval Medical Center of PLA Naval Medical University (Second Military Medical University) Shanghai China.ORCID 0000-0001-6979-4505
Yang-Kai WangNaval Medical Center of PLA Naval Medical University (Second Military Medical University) Shanghai China.ORCID 0000-0002-7254-0335

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstaglandin E METHODS AND

resultsRVLM microinjections of PGE

conclusionsCentral Ang II induces the accumulation of RVLM PGE

Indexed as

Angiotensin IICyclooxygenase 2DinoprostoneHypertensionJanus Kinase 2Medulla OblongataOxidative StressSTAT3 Transcription FactorAnimalsDisease Models, AnimalMaleMicroinjectionsRatsRats, Inbred SHRRats, Inbred WKYSignal TransductionAngiotensin IICyclooxygenase 2DinoprostoneJak2 protein, ratJanus Kinase 2Ptgs2 protein, ratStat3 protein, ratSTAT3 Transcription Factorangiotensin IIcyclooxygenasehypertensionoxidative stressprostaglandin E2rostral ventrolateral medulla

Identifiers

PMID39817553
PMCPMC12054422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.