Evidence map›Paper›PMID 39817539›Full record

ArticleJournal of the American Heart Association2025

Kidney Arteriolar Responses to Liver-Targeted Small Interference RNA Targeting Angiotensinogen in Diabetic Rats: Comparison With Other Renin-Angiotensin System Blockers.

Edwyn O Cruz-López, Alexandre G Martini, Don Foster, Ivan Zlatev, Anne Kasper, Maria Luisa S Sequeira-Lopez, Ariel Gomez, A H Jan Danser

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Edwyn O Cruz-LópezDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine Erasmus University Medical Center Rotterdam The Netherlands.ORCID 0000-0002-4810-5720
Alexandre G MartiniDepartment of Pediatrics Child Health Research Center, University of Virginia School of Medicine Charlottesville VA.
Don FosterAlnylam Pharmaceuticals Cambridge MA.
Ivan ZlatevAlnylam Pharmaceuticals Cambridge MA.ORCID 0000-0003-2797-3032
Anne KasperAlnylam Pharmaceuticals Cambridge MA.
Maria Luisa S Sequeira-LopezDepartment of Pediatrics Child Health Research Center, University of Virginia School of Medicine Charlottesville VA.ORCID 0000-0002-4459-7940
Ariel GomezDepartment of Pediatrics Child Health Research Center, University of Virginia School of Medicine Charlottesville VA.ORCID 0000-0002-5124-8255
A H Jan DanserDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine Erasmus University Medical Center Rotterdam The Netherlands.ORCID 0000-0002-5052-3585

Funding

Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8M
Renin cell identity and blood pressure homeostasisR01HL148044 · NHLBI · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2020 to 2023
$2.7M
NHLBI NIH HHS R01 HL148044NIDDK NIH HHS P50 DK096373
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

angiotensinogenarteriolar concentric thickeningdiabeteshypertensionsmall interfering RNA

Identifiers

PMID39817539
PMCPMC12054473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.