ArticleJACC. Advances2024
Incidence and Progression of Diastolic Dysfunction in People With HIV in Tanzania: A Comparative Cohort.
Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Longitudinal Blood Pressure Trajectory and Subclinical Echocardiographic Measures of Cardiovascular Disease in People Living With HIV: A Comparative Prospective Cohort Study.Journal of the American Heart Association · 2026Article
- Echocardiography in HIV Disease.Current cardiology reports · 2026Review
- Ambulatory Blood Pressure Patterns and Left Ventricular Mass Index in Tanzanian Adults Living with and without HIV.Global heart · 2026Article
- Article
- Bridging Global Gaps in Cardiovascular Health: Catalyzing Action.JACC. Advances · 2024Article
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Authors and funding
18 authors.
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Abstract
Background: People living with HIV (PLWH) have a higher prevalence of diastolic dysfunction and left ventricular hypertrophy (LVH) in cross-sectional studies. Longitudinal data are lacking, especially from Africa. Objectives: The aim was to examine: 1) the incidence of diastolic dysfunction in PLWH compared to community controls in Tanzania; 2) the progression of diastolic function and LVH in PLWH after antiretroviral therapy initiation; and 3) traditional, endemic, and HIV-specific risk factors for diastolic function and LVH. Methods: This was a prospective longitudinal cohort of PLWH and HIV-uninfected controls who had an echocardiogram at enrollment and in follow-up. Adjusted Cox proportional HR models were used to determine the incidence of diastolic dysfunction, and multivariable mixed effects regressions were used to determine the progression and risk factors for diastolic function. Results: A total of 781 participants (367 PLWH) were followed for up to 5 years. There was no difference in incidence of diastolic dysfunction by HIV serostatus (aHR: 0.93 [95% CI: 0.61-1.42]). Baseline differences in echo parameters prior to antiretroviral therapy initiation resolved within 3 years of treatment for LVH (baseline difference = 3.57 g/m Conclusions: The incidence of diastolic dysfunction was similar in PLWH and HIV-uninfected controls. Efforts to prevent diastolic heart failure in Africa must focus on addressing hypertension and obesity while also investigating nontraditional risk factors.
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