Evidence map›Paper›PMID 39816842›Full record

ArticleFrontiers in parasitology2023

Optimizing the xWORM assay for monitoring hookworm larvae motility.

Danica Lennox-Bulow, Luke Becker, Alex Loukas, Jamie Seymour, Michael Smout

Abstract read
In one paragraph

Article in Frontiers in parasitology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Danica Lennox-BulowTropical Australian Stinger Research Unit, James Cook University, Cairns, QL, Australia.
Luke BeckerAustralian Institute of Tropical Health and Medicine (AITHM), James Cook University, Cairns, QL, Australia.
Alex LoukasAustralian Institute of Tropical Health and Medicine (AITHM), James Cook University, Cairns, QL, Australia.
Jamie SeymourTropical Australian Stinger Research Unit, James Cook University, Cairns, QL, Australia.
Michael SmoutAustralian Institute of Tropical Health and Medicine (AITHM), James Cook University, Cairns, QL, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parasitic worms (helminths) infect almost all taxa across the animal kingdom, and pose significant challenges to public health and economies, particularly in developing countries. To address this problem, researchers have developed various tools to measure the motility and viability of helminths. However, the conditions used in anthelmintic screening assays are often not optimized, and can vary considerably between research teams. These unoptimized conditions may impact novel drug screens, as little is known about the effects of different conditions on the health of the target parasites. To improve future research, this study determined the effects of key assay parameters including, media type, media concentration, in-well parasite density, and assay duration on the infective third-stage larva (L3) of two types of hookworms, namely

Indexed as

assay conditionsdrug screening and discoveryhelminth culturehookworm larvaemethod optimizationxWORM

Identifiers

PMID39816842
PMCPMC11731822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.