Evidence map›Paper›PMID 39816829›Full record

ArticleFrontiers in parasitology2023

Identification of biomarker candidates for filarial parasite infections by analysis of extracellular vesicles.

Devyn Yates, Lucia S Di Maggio, Bruce A Rosa, Robert W Sprung, Petra Erdmann-Gilmore, R Reid Townsend, Philip J Budge, Joseph Kamgno, Makedonka Mitreva, Gary J Weil and 1 more

Abstract read
In one paragraph

Article in Frontiers in parasitology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Frontiers in immunology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Devyn YatesDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Lucia S Di MaggioDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Bruce A RosaDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Robert W SprungDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Petra Erdmann-GilmoreDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
R Reid TownsendDivision of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Philip J BudgeDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Joseph KamgnoCentre for Research on Filariasis and other Tropical Diseases, Yaoundé, Cameroon.
Makedonka MitrevaDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Gary J WeilDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Peter U FischerDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical ProjectsR24GM136766 · NIGMS · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2020 to 2022
$2.3M
Gates Foundation INV-021433NCATS NIH HHS UL1 TR000448NCI NIH HHS P30 CA091842NIGMS NIH HHS P41 GM103422NIGMS NIH HHS R24 GM136766
6 · The paper itself

Abstract

Background: Improved diagnostic tools are needed for detecting active filarial infections in humans. Tests are available that detect adult Methods: Vesicles were isolated using VN96-affinity purification from supernatants of short-term Results: Vesicles from Mf cultures contained more than 300 Discussion: Extracellular vesicles released by filarial parasites

Indexed as

biomarkerBrugia malayiextracellular vesiclesfilarial parasiteLoa loa

Identifiers

PMID39816829
PMCPMC11732158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.