Evidence map›Paper›PMID 39816788›Full record

ArticleACS pharmacology & translational science2025

Pyrazinyl-Substituted Aminoazoles as Covalent Inhibitors of Thrombin: Synthesis, Structure, and Anticoagulant Properties.

Lukas Imberg, Alena I Siutkina, Catharina Erbacher, Judith Schmidt, Darius F Broekmans, Ruzanna A Ovsepyan, Constantin G Daniliuc, Ellen Gonçalves de Oliveira, Mateus Sá Magalhães Serafim, Anthony J O'Donoghue and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. IUCrData · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lukas ImbergInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.
Alena I SiutkinaInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.
Catharina ErbacherInstitute of Inorganic and Analytical Chemistry, University of Münster, 48149 Münster, Germany.
Judith SchmidtInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.
Darius F BroekmansInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.
Ruzanna A OvsepyanCenter for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 119991 Moscow, Russia.
Constantin G DaniliucInstitute for Organic Chemistry, University of Münster, 48149 Münster, Germany.ORCID https://orcid.org/0000-0002-6709-3673
Ellen Gonçalves de OliveiraCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States.
Mateus Sá Magalhães SerafimCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States.
Anthony J O'DonoghueCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, California 92093, United States.
Thanigaimalai PillaiyarInstitute of Pharmacy, Pharmaceutical/Medicinal Chemistry, Eberhard Karls University Tübingen, 72076 Tübingen, Germany.ORCID https://orcid.org/0000-0001-5575-8896
Mikhail A PanteleevCenter for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 119991 Moscow, Russia.
Antti PosoSchool of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.ORCID https://orcid.org/0000-0003-4196-4204
Svetlana A KalininaInstitute of Food Chemistry, University of Münster, Münster 48149, Germany.ORCID https://orcid.org/0000-0001-7564-8213
Marcel BermúdezInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.ORCID https://orcid.org/0000-0002-7421-3282
Katrin NekipelovPharmaceutical Institute, University of Bonn, 53121 Bonn, Germany.
Gerd BendasPharmaceutical Institute, University of Bonn, 53121 Bonn, Germany.ORCID https://orcid.org/0000-0002-8667-7201
Uwe KarstInstitute of Inorganic and Analytical Chemistry, University of Münster, 48149 Münster, Germany.ORCID https://orcid.org/0000-0002-1774-6787
Dmitrii V KalininInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.ORCID https://orcid.org/0000-0003-2717-5364

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents a novel series of

Identifiers

PMID39816788
PMCPMC11730114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.