ArticleInfectious Disease Modelling2025
Treatment failure and the threshold of disease extinction.
Article in Infectious Disease Modelling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Modelling the Effects of Treatment Failure on the Minor Outbreak Duration for Carrier-Related Infectious Disease.Epidemiologia (Basel, Switzerland) · 2026Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Antibiotic treatment failure related to carriers poses a serious problem to physicians and epidemiologists. Due to the sparsity of data, assessing the role in infection dynamics is difficult. In this study, we examined the possibility that a particular therapeutic effectiveness will be regarded as the disease extinction threshold through the mathematical modelling approach. Including the treatment state in the generic epidemic model with carrier allows us to describe the role of carriers in the treatment failure. The parameterized extinction thresholds were derived via the basic reproduction number for deterministic model, and via the Jury stability criterion for the stochastic model. Existence conditions for the stochastic threshold were derived without the exact formula of the spectral radius of the expectation matrix. The results show that the transmissibility of carrier is necessary for the extinction threshold via treatment failure. The expected extinction threshold may occur subject to the certain range of the transmission potential of the symptomatic infection. This existence conditions are independent of the rate at which the carriers undergo treatment and can be used to support a control strategy.
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