Evidence map›Paper›PMID 39816637›Full record

ArticleBiomedicine hub

Meconium Influences Pulmonary Short-Chain Fatty Acid Concentration in Porcine Meconium Aspiration Model.

Harry Ramcharran, Auyon Ghosh, Qinghe Meng, Guanqun Li, Evan Skakel Chernov, Mark Lutz, Heidi M Mansour, Joshua Satalin, Sarah Satalin, Donald P Gaver and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicine hub. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Harry RamcharranDepartment of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Auyon GhoshDepartment of Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
Qinghe MengDepartment of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Guanqun LiDepartment of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.
Evan Skakel ChernovDepartment of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Mark LutzDepartment of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Heidi M MansourCenter for Translational Science, Florida International University, Port Saint Lucie, FL, USA.
Joshua SatalinDepartment of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
Sarah SatalinDepartment of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Donald P GaverDepartment of Bioengineering, Tulane University, New Orleans, LA, USA.
Jason H T BatesDepartment of Bioengineering, University of Vermont, Burlington, VT, USA.
Gary NiemanDepartment of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.
Michaela Kollisch-SinguleDepartment of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The factors influencing meconium aspiration syndrome (MAS) severity remain poorly understood. In a piglet model of MAS, we hypothesized the respiratory microbiome would reflect the bacterial signature of meconium with short-chain fatty acid (SCFA) accumulation as a byproduct of bacterial fermentation. Methods: Cesarean section at approximately 115-day term was performed on two sows. Male (9) and female (3) piglets were delivered, instrumented, anesthetized, and randomized into a Control ( Results: The MAS group had significantly higher fluid and vasopressor requirements than the Control group ( Conclusions: Meconium may host a microbiome with byproducts that interact with the pulmonary epithelium and influence lung injury severity in MAS.

Indexed as

Meconium aspiration syndromeMicrobiomePropionic acidShort-chain fatty acids

Identifiers

PMID39816637
PMCPMC11735036

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.