ArticleCureus2024
A Case Report of an Immature Pituitary-Specific Transcription Factor 1 (PIT1)-Lineage Pituitary Neuroendocrine Tumor Along With Its Cytology and Ultrastructural Studies.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Immature pituitary-specific transcription factor 1 (PIT1)-lineage pituitary neuroendocrine tumors are composed of PIT1-lineage cells with cytological atypia and limited differentiation. These tumors are rare and no cytological features of this neoplasm have been reported. This study is the first to report the cytological features of an immature PIT1-lineage tumor. A 15-year-old boy with mild and asymptomatic hyperprolactinemia underwent endoscopic endonasal transsphenoidal resection of a sellar tumor mass associated with areas of calcification. Intraoperative smear cytology revealed high cellularity and discohesive cells. Large, bizarre nuclei, nuclear irregularities, and pseudonuclear inclusions were present. Histological examination also revealed large nuclei and nuclear irregularities. Immunohistochemically, the tumor cells were diffusely positive for PIT1 and focally positive for thyroid-stimulating hormone, growth hormone, and prolactin. Ultrastructural examination of the tumor specimen revealed large cells with pseudonuclear inclusions and nuclear irregularities. These findings are consistent with those of immature PIT1-lineage tumors. Smear cytology findings, including large cells, pseudonuclear inclusion bodies, prominent nucleoli, epithelial clusters, and mitotic activity, are useful for the rapid intraoperative diagnosis of immature PIT1-lineage tumors.
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