ArticleBrain communications2025
Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.
Erratum issuedAbstract read
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Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Aging-related matrix metallopeptidase 10 and osteopontin levels are associated with pathology, cognitive decline, and age at onset in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Proteomic polygenic risk scores of age-related plasma protein levels reveal a role for Metalloproteinase inhibitor 2 (TIMP2) in cognitive performance.Neurobiology of aging · 2026Article
- Immortality Reconsidered: Clinical Challenges at the Frontier of Plastic Surgery.Journal of clinical medicine · 2025Review
- Know your brain aging to know your resilience in neurodegenerative diseases.Brain communications · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
45 authors.
Kaitlin B CasalettoDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0003-0610-6933
Rowan SalonerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
John KornakDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USA.
Adam M StaffaroniDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
Saul VilledaDepartment of Anatomy, University of California, San Francisco, CA 94143, USA.
Emily PaolilloDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
Anna M VandeBunteDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
Claire J CadwalladerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
Argentina Lario LagoDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
Julia WebbDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
Coty ChenDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
Katya RascovskyDepartment of Neurology and Penn Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA 19104, USA.
Toji MiyagawaDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Eliana Marisa RamosDepartment of Neurology, University of California, Los Angeles, CA 90095, USA.
Joseph C MasdeuDepartment of Neurology, Houston Methodist, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0001-9955-6954
Alexander PantelyatDepartment of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA.
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, Division of Neurology, University of Toronto, Toronto, ON M5S 3H2, Canada.
Andrea BozokiDepartment of Neurology, University of North Carolina, Chapel Hill, NC 27599, USA.
Peter S PressmanDepartment of Neurology, University of Colorado, Aurora, CO 80045, USA.
Rosa RademakersNeurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, University of Antwerp-Biomedical sciences, Antwerp, 2610, Belgium.
Walter KremersDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Ryan DarbyDepartment of Neurology, Vanderbilt University, Nashville, TN 37212, USA.
Kyan YounesDepartment of Neurology, Stanford University, Palo Alto, CA 94304, USA.
Belen PascualDepartment of Neurology, Houston Methodist, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0002-4467-7406
Nupur GhoshalDepartments of Neurology and Psychiatry, Washington University, St. Louis, MO 63110, USA.
Maria LapidDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
Ian R A MackenzieDepartment of Pathology, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Jingyao LiNovartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Ging-Yuek Robin HsiungDepartment of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Jacob N HallThe Neurology Center of Southern California, Carlsbad, CA 92011, USA.
Maya V YutsisDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA 94304, USA.
Irene LitvanDepartment of Neurosciences, University of California, La Jolla, CA 92037, USA.ORCID https://orcid.org/0000-0002-3485-3445
Victor W HendersonDepartments of Epidemiology and Population Health and of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA 94304, USA.
Rajeev SivasankaranNovartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.ORCID https://orcid.org/0000-0003-3917-0181
Katie WorringerNovartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Kimiko Domoto-ReillyDepartment of Neurology, University of Washington, Seattle, WA 98195, USA.
Allison SynderNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20814, USA.
Joseph LoureiroNovartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Joel H KramerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
Hilary HeuerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94159, USA.
Leah K ForsbergDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Howard J RosenDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
Bradley BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0002-4153-8187
Julio C RojasDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
Adam L BoxerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MResearch Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3MStanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0MLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9MWorking Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI GREICIUS, MICHAEL D · 2015 to 2019
$7.9MTraining - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4MUnraveling the intersection of synaptic biology, lifestyle, and cognitive resilienceR01AG072475 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2021 to 2025
$4.3MLeveraging mouse and human models to investigate neuroprotective effects of blood-derived exerkines in Alzheimer's diseaseR56AG082414 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B, VILLEDA, SAUL A · 2023 to 2023
$1.2MProteomics for fluid biomarker discovery in frontotemporal dementiaK23AG059888 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROJAS-MARTINEZ, JULIO CESAR · 2019 to 2023
$995kNIA NIH HHS K23 AG059888NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066515NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG072475NIA NIH HHS R56 AG082414NIA NIH HHS U01 AG045390NIA NIH HHS U19 AG063911NIA NIH HHS U24 AG021886NINDS NIH HHS U54 NS092089
Abstract
The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance and combined effects of these factors for humans is unclear. We examined five previously identified brain rejuvenation factors in cerebrospinal fluid of adults with autosomal dominant forms of frontotemporal dementia and sporadic Alzheimer's disease. Our frontotemporal dementia cohort included 100 observationally followed adults carrying autosomal dominant frontotemporal dementia mutations (M
Indexed as
Alzheimer’s diseasebiomarkerscerebrospinal fluidfrontotemporal dementiaheterochronic parabiosis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.