Evidence map›Paper›PMID 39816166›Full record

ArticleDrug target insights

Characterization and enhanced antibiofilm activity of

Abhay P Mishra, Masande Yalo, Jennifer Nambooze, Carolina H Pohl, Gabré Kemp, Lekgoana K Setsiba, Motlalepula G Matsabisa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug target insights. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abhay P MishraDepartment of Pharmacology, University of Free State, Bloemfontein - South Africa.ORCID https://orcid.org/0000-0002-2224-0852
Masande YaloDepartment of Chemistry, Cape Peninsula University of Technology, Cape Town - South Africa.ORCID https://orcid.org/0000-0001-9860-1629
Jennifer NamboozeDepartment of Chemistry, University of Free State, Bloemfontein - South Africa.ORCID https://orcid.org/0000-0003-0950-7652
Carolina H PohlDepartment of Microbiology and Biochemistry, University of Free State, Bloemfontein - South Africa.
Gabré KempDepartment of Microbiology and Biochemistry, University of Free State, Bloemfontein - South Africa.
Lekgoana K SetsibaDepartment of Microbiology and Biochemistry, University of Free State, Bloemfontein - South Africa.ORCID https://orcid.org/0000-0001-9487-5286
Motlalepula G MatsabisaDepartment of Pharmacology, University of Free State, Bloemfontein - South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: Phytochemicals from the methanol extract were analyzed by LC-MS, the XTT assay was used for metabolic activity, and morphological characteristics were examined using scanning electron microscopy (SEM). Molecular docking screening of identified compounds in Results: The LC-MS analysis detected 17 possible phytochemicals. The methanol extract showed a dose-dependent inhibition of biofilm formation, with maximum inhibition of ~60% observed at 240 μg/ml, and inhibition by fluconazole increased from 32% to 76% as the concentration increased from 15 to 240 μg/ml. The combination of Conclusion: Consequently, the findings indicate that compounds in the

Indexed as

A. muricataCandida albicansFluconazoleLC-MSSynergismXTT assay

Identifiers

PMID39816166
PMCPMC11729473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.