Evidence map›Paper›PMID 39816155›Full record

ArticleBiomedical optics express2025

Response of capillaries and small arterioles to full-field flicker is not dependent on local ganglion cell thickness.

Marcelina Sobczak, Brittany R Walker, Thomas Gast, Nicholas Cassavaugh, Alessandra Carmichael-Martins, Stephen A Burns

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marcelina SobczakSchool of Optometry, Indiana University, Bloomington, IN, USA.ORCID https://orcid.org/0000-0003-0694-3547
Brittany R WalkerSchool of Optometry, Indiana University, Bloomington, IN, USA.
Thomas GastSchool of Optometry, Indiana University, Bloomington, IN, USA.
Nicholas CassavaughSchool of Optometry, Indiana University, Bloomington, IN, USA.
Alessandra Carmichael-MartinsSchool of Optometry, Indiana University, Bloomington, IN, USA.ORCID https://orcid.org/0000-0002-1899-6497
Stephen A BurnsSchool of Optometry, Indiana University, Bloomington, IN, USA.ORCID https://orcid.org/0000-0001-5348-035X

Funding

Adaptive Optics Imaging of Human Retinal Vascular Structure and FunctionR01EY024315 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI BURNS, STEPHEN A · 2015 to 2024
$4.3M
NEI NIH HHS R01 EY024315
6 · The paper itself

Abstract

To measure the influence of ganglion cell layer (GCL) thickness on the changes in size and red blood cell (RBC) flow in small retinal vessels evoked by full-field flicker. We used a dual-beam adaptive optics scanning laser ophthalmoscope to image 11 healthy young controls in two retinal areas with significantly different GCL thicknesses. All capillaries and arterioles of the superficial vascular plexus were responsive to the flicker stimulation. Average lumen dilation and RBC flow changes were greater in capillaries than in arterioles (vasodilation: 10.9%, 6.7%; RBC flow: 51%, 38%, respectively). No statistically significant differences regarding relative lumen diameter, RBC velocity, or RBC flow were found with respect to GCL thickness, or vessel size.

Identifiers

PMID39816155
PMCPMC11729286

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.