ArticleBiomedical optics express2025
Development and performance validation of an affordable and portable high-resolution darkfield polarization-sensitive multispectral imaging microscope for the assessment of radiation dermatitis and fibrosis.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology.American journal of clinical dermatology · 2026Review
- High-speed, wide-field, fiber-based PS-OCT system with real-time surface Stokes feedback for circular input polarization.Biomedical optics express · 2026Article
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Authors and funding
11 authors.
Funding
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Abstract
Radiation therapy (RT) is widely used for cancer treatment but is found with side effects of radiation dermatitis and fibrosis thereby calling for timely assessment. Nevertheless, current clinical assessment methods are found to be subjective, prone to bias, and accompanied by variability. There is, therefore, an unmet clinical need to explore a new assessment technique, ideally portable and affordable, making it accessible to less developed regions too. We developed an affordable (16764 CNY) and portable high-resolution ((3.91 μm) darkfield polarization-sensitive multispectral imaging (PS-MSI) microscope. The implementation of the Monte Carlo simulation on the PS multi spectra allows the quantitative analysis of physiological parameters (i.e., blood volume fraction (BVF) and oxygen saturation of hemoglobin) at different skin layers for the dermatitis assessment. Further derivation of the degree of linear polarization (DOLP) reflects randomly distributed collagen fibers associated with fibrosis for the fibrosis assessment. PS-MSI microscope developed revealed a significant decrease (p < 0.001, analysis of variance, ANOVA) in the DOLP associated with fibrosis like scar tissue, and significant (
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Registered trials
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