Evidence map›Paper›PMID 39816066›Full record

ArticleNarra J2024

Secretome from hypoxic mesenchymal stem cells as a potential therapy for ischemic stroke: Investigations on

Sisca Silvana, Iskandar Japardi, Muhammad Rusda, Rini S Daulay, Agung Putra, Irawan Mangunatmadja, Dewi M Darlan, Sri Sofyani, Yana Andreas

Abstract read
In one paragraph

Article in Narra J, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sisca SilvanaPhilosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Iskandar JapardiPhilosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Muhammad RusdaPhilosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Rini S DaulayPhilosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Agung PutraStem Cell and Cancer Research (SCCR), Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Indonesia.
Irawan MangunatmadjaDepartment of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Dewi M DarlanPhilosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Sri SofyaniPhilosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Yana AndreasFaculty of Medicine, Universitas HKBP Nommensen, Medan, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is a sudden onset of neurological deficit resulting from a blockage in cerebral blood vessels, which can lead to brain tissue damage, chronic disability, and increased risk of mortality. Secretome from hypoxic mesenchymal stem cells (SH-MSC) is a potential therapy to improve neurological deficit by increasing the expression of vascular endothelial growth factor (VEGF) and reducing glial fibrillary acidic protein (GFAP). These effects can reduce the infarction area of ischemic stroke. Therefore, the aim of this study was to analyze the effect of 150 μL and 300 μL SH-MSC injection on

Indexed as

Glial Fibrillary Acidic ProteinIschemic StrokeMesenchymal Stem CellsMesenchymal Stem Cell TransplantationSecretomeVascular Endothelial Growth Factor AAnimalsDisease Models, AnimalInfarction, Middle Cerebral ArteryMaleRatsGfap protein, ratGlial Fibrillary Acidic ProteinVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratGFAPischemic strokesecretomestem cellVEGF

Identifiers

PMID39816066
PMCPMC11732002

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.