Evidence map›Paper›PMID 39816028›Full record

ArticleJournal of gastrointestinal oncology2024

Leptin increases chemosensitivity by inhibiting

Xiuwei Mi, Huihui Yao, Yang Lu, Mei Yang, Yi Yang, Dong Fang, Songbing He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastrointestinal oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Journal of gastrointestinal oncology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiuwei Mi *Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, China.
Huihui Yao *Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, China.
Yang LuDepartment of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, China.
Mei YangThe Joint Cancer Research Institute of Soochow University and SANO Medical Laboratories, Suzhou, China.
Yi YangDepartment of Oncological Surgery, Kunshan Traditional Hospital Affiliated to Nanjing University of Chinese Medicine, Kunshan, China.
Dong FangDepartment of Anorectal Surgery, Kunshan Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, China.
Songbing HeDepartment of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chemoresistance is a major cause of treatment failure in advanced colorectal cancer (CRC), severely impacting patient survival and quality of life. While conventional chemotherapy regimens can somewhat control tumor progression, their effectiveness is frequently compromised by the development of drug resistance in cancer cells. The aim of this study is to verify and elucidate the specific mechanisms by which leptin enhances chemosensitivity in CRC, providing valuable insights for the development of new combination chemotherapy options. Methods: We examined the link between CRC chemoresistance and fatty-acid metabolism driven by the high expression of carnitine palmitoyltransferase-1b ( Results: Leptin significantly enhanced CRC cells' chemosensitivity to cisplatin by downregulating Conclusions: These findings indicate that leptin, through modulation of

Indexed as

carnitine palmitoyltransferase-1b (CPT1B)chemosensitivityColorectal cancer (CRC)leptin

Identifiers

PMID39816028
PMCPMC11732356

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.