ArticleAdvances in radiation oncology2025
Cone Beam Online Adaptive Radiation Therapy: A Promising Approach for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma?
Article in Advances in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Mechanically assisted non-invasive ventilation for liver SABR: Improve CBCT, treat more accurately.Clinical and translational radiation oncology · 2025Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Daily online adaptive radiation therapy (oART) opens the opportunity to treat gastric mucosa-associated lymphoid tissue (MALT) lymphoma with a reduced margin. This study reports our early experience of cone beam computed tomography (CBCT)-based daily oART treating gastric MALT lymphoma with breath-hold and reduced margins. Methods and Materials: Ten patients were treated on a CBCT-based oART system. Organs at risk (OARs) and the clinical target volume (CTV) were adjusted based on the daily CBCT. Planning target volume (PTV) was derived from the CTV with a 0.5 to 0.7 cm margin with breath-hold. Multiple beam arrangements were compared during the preplanning phase to ensure minimal monitor unit (MU) for patient comfort and breath-hold reproducibility. For 108 fractions from the 10 patients, the PTV, CTV coverage, and Paddick conformity index (CI) were compared between the adapted and scheduled plans. The MU, Paddick CI, and gradient index were compared using relative percentage differences between the adapted plans and preplans. The OAR doses from 106 fractions across 9 patients were reported for the preplans, adapted plans, and scheduled plans. The time statistics for each step of the clinical workflow were recorded and reported for 93 treatment fractions from 9 patients. Results: The PTV volume varied from -37.1% to 90.5% (11.7% ± 18.5%) throughout treatments across all patients. The adapted plan was chosen as the treatment plan for each fraction because of superior PTV and CTV coverage while maintaining a similar OAR dose. The PTV and CTV coverage for the adapted and scheduled plans was V Conclusion: A CBCT-based oART system with the proposed workflow is feasible for treating patients with gastric MALT lymphoma using a reduced PTV margin while maintaining excellent target coverage within a reasonable time, resulting in consistent adapted plan quality. This approach can be expanded to a larger cohort of gastrointestinal patients.
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Registered trials
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