Evidence map›Paper›PMID 39815807›Full record

ArticleHaematologica2025

Targeting the membrane-proximal domain of CD33 to maximize the efficacy of natural killer cell-based immunotherapies.

Sheryl Y T Lim, Frances M Cole, George S Laszlo, Margaret C Lunn-Halbert, Jenny Huo, Junyang Li, Allie R Kehret, Roland B Walter

Abstract read
In one paragraph

Article in Haematologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sheryl Y T LimTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Frances M ColeTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
George S LaszloTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Margaret C Lunn-HalbertTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Jenny HuoTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Junyang LiTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Allie R KehretTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Roland B WalterTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Department of Medicine, Division of Hematology and Oncology, University of Washington, Seattle, WA, USA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. rwalter@fredhutch.org.

Funding

Stem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1M
Optimizing the Efficacy and Safety of CD33-Targeted Immunotherapy for Acute Myeloid Leukemia and Other CD33+ DisordersR50CA274319 · NCI · FRED HUTCHINSON CANCER CENTER · PI GEORGE S LASZLO · 2023 to 2026
$648k
Optimizing NK Cell-Engaging Bispecific Antibody Therapy Targeting CD33R21CA259779 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI WALTER, ROLAND BRUNO · 2021 to 2022
$448k
NCI NIH HHS R21 CA259779NCI NIH HHS R50 CA274319NIDDK NIH HHS U54 DK106829
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39815807
PMCPMC12050945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.