Evidence map›Paper›PMID 39815783›Full record

ArticleJournal of extracellular vesicles2025

Helminth extracellular vesicles co-opt host monocytes to drive T cell anergy.

Anne Borup, Mohammad Farouq Sharifpour, Litten S Rossen, Bradley Whitehead, Anders T Boysen, Rikke Olesen, Anja B Bohn, Andrea Ridolfi, Marco Brucale, Francesco Valle and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Anne BorupDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-7710-4391
Mohammad Farouq SharifpourAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.ORCID https://orcid.org/0000-0002-7950-955X
Litten S RossenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Bradley WhiteheadDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0009-0000-8231-1707
Anders T BoysenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-0192-1413
Rikke OlesenDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Anja B BohnDepartment of Biomedicine, FACS Core Facility, Aarhus University, Aarhus, Denmark.
Andrea RidolfiDepartment of Physics and Astronomy and LaserLaB Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Marco BrucaleConsorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (CSGI), University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0001-7244-4389
Francesco ValleConsorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (CSGI), University of Florence, Florence, Italy.
Lucia PaoliniConsorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (CSGI), University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-2737-1090
Annalisa RadeghieriConsorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (CSGI), University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-4410-5272
Paolo BergeseConsorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase (CSGI), University of Florence, Florence, Italy.
Kim MilesAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
Margaret VeitchAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
Tamara ThomasAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
Roland RuscherAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
Phurpa WangchukAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
Paul GiacominAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
Alex LoukasAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
Peter NejsumDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Funding

Horizon 2020 Framework Programme DFF-6111-00521National Health and Medical Research Council, Investigator Grant 2008450
6 · The paper itself

Abstract

Parasitic helminths secrete extracellular vesicles (EVs) into their host tissues to modulate immune responses, but the underlying mechanisms are poorly understood. We demonstrate that Ascaris EVs are efficiently internalised by monocytes in human peripheral blood mononuclear cells and increase the percentage of classical monocytes. Furthermore, EV treatment of monocytes induced a novel anti-inflammatory phenotype characterised by CD14

Indexed as

AscarisClonal AnergyExtracellular VesiclesMonocytesT-LymphocytesAnimalsColitisHost-Parasite InteractionsHumansMiceMice, Inbred C57BLAscariscolitisextracellular vesicleshelminthhost‐parasite interactionimmune modulationinflammatory bowel diseasemonocytes

Identifiers

PMID39815783
PMCPMC11735955

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.