SynthesisJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
The effect of continuous positive airway pressure therapy on intraocular pressure in patients with OSA: a systematic review and meta-analysis.
Synthesis in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- The Pathophysiological Association Between Obstructive Sleep Apnea and Glaucoma: A Current Update.Journal of clinical medicine · 2026Review
- Choroidal Detachment in a Patient on a CPAP Therapy.Case reports in ophthalmological medicine · 2026Article
- Multimodal Assessment of Ocular Parameters in Patients with Severe Obstructive Sleep Apnea with Emphasis on Retinal Structural Changes.Life (Basel, Switzerland) · 2025Article
- CPAP Use and Retinal Disease Risk in Obstructive Apnea: A Cohort Study.Vision (Basel, Switzerland) · 2025Article
- Neuro-Ophthalmological Disorders Associated with Obstructive Sleep Apnoea.International journal of molecular sciences · 2025Review
- Glaucoma After Dark: Sleep, Circadian Stress, and Unmeasured Drivers of Disease.Journal of current glaucoma practiceArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo assess the effect of continuous positive airway pressure (CPAP) therapy on intraocular pressure in patients with obstructive sleep apnea.
methodsThe search was performed in Ovid Medline and Embase database, then followed by a manual bibliography search. Abstract search and screening were independently performed followed by eligible full-text versions reviewed. Then disagreements were discussed in a group.
resultsThis systematic review and meta-analysis considered 15 studies with 495 participants. The pooled mean intraocular pressure after CPAP therapy shows no significant difference compared to the baseline (mean difference, 0.58 mmHg; 95% confidence interval, -0.33 to 1.19). Subgroup analysis shows significantly higher intraocular pressure after in-laboratory positive airway pressure titration and after long-term CPAP use (mean difference, 4.28 mmHg; 95% confidence interval, 0.91-7.66; mean difference, 0.45 mmHg; 95% confidence interval, 0.07-0.83; respectively). Ocular perfusion pressure was also significantly decreased after CPAP therapy (mean difference, -2.15 mmHg; 95% confidence interval, -3.50 to -0.80). The pooled data showed no significant difference in retinal nerve fiber layer thickness and macular layer thickness.
conclusionsAfter long-term treatment CPAP therapy, there is a significant increase in intraocular pressure in patients with obstructive sleep apnea and a decrease in ocular perfusion pressure, but no significant difference in other ophthalmologic parameters is shown. For this reason, CPAP usage in patients with glaucoma necessitates to be done cautiously. SYSTEMATIC REVIEW REGISTRATION: Registry: PROSPERO; Name: International Prospective Register of Systematic Reviews; URL: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022370734; Identifier: CRD42022370734. CITATION: Kongchan P, Banhiran W, Chirapapaisan N, Kasemsuk N. The effect of continuous positive airway pressure therapy on intraocular pressure in patients with OSA: a systematic review and meta-analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.