Evidence map›Paper›PMID 39815717›Full record

ArticleEndocrinology, diabetes & metabolism2025

Exploring the Predictive Role of 11-Oxyandrogens in Diagnosing Polycystic Ovary Syndrome.

Armaiti Parvez Mody, Maya Beth Lodish, Richard Joseph Auchus, Adina F Turcu, Fei Jiang, Heather Gibson Huddleston

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, diabetes & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Article
  5. Living with PCOS: A Narrative of its Biology, Diagnosis, and Evolving Treatment.Endocrine, metabolic & immune disorders drug targets · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Armaiti Parvez ModyDivision of Pediatric Endocrinology, University of California, Davis, California, USA.ORCID 0000-0001-6341-0144
Maya Beth LodishDivision of Pediatric Endocrinology, University of California, San Francisco, California, USA.ORCID 0000-0002-3188-377X
Richard Joseph AuchusDivision of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA.
Adina F TurcuDivision of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA.
Fei JiangDivision of Epidemiology & Biostatistics, University of California, San Francisco, California, USA.
Heather Gibson HuddlestonDivision of Reproductive Endocrinology and Infertility, University of California, San Francisco, California, USA.

Funding

Training Program in Pediatric EndocrinologyT32DK007161 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian J Feldman, STEPHEN E GITELMAN · 1986 to 2026
$6.2M
The contemporary endocrinology of congenital adrenal hyperplasiaK08DK109116 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TURCU, ADINA F · 2016 to 2020
$832k
Michigan Institute for Clinical and Health Research U064177NIDDK NIH HHS 1K08DK109116NIDDK NIH HHS K08 DK109116NIDDK NIH HHS T32 DK007161
6 · The paper itself

Abstract

contextHyperandrogenism is a hallmark of polycystic ovary syndrome (PCOS), yet the androgen(s) responsible remain ambiguous. Recent studies have suggested that 11-oxygenated C

objectiveTo investigate the utility of 11-oxyandrogens to differentiate women with and without PCOS relative to classical androgens. DESIGN

settingCase-control study performed at a PCOS clinic and research center in an academic setting. PATIENTS: 114 women with PCOS and 78 healthy controls.

interventionsUsing the PCOS Tissue Bank, serum samples and data from 114 women registered from 2013 to 2017 between the ages of 18-40 years, were obtained and classified using Rotterdam PCOS criteria. Data were compared to 78 healthy women of similar age, with serum samples obtained between 2017 and 2020. 11-oxyandrogens and sex steroids were measured using mass spectrometry, and their associations to Rotterdam PCOS, age, and BMI were assessed.

main outcome measures11-oxyandrogens and sex steroids.

resultsTotal testosterone, androstenedione, and four 11-oxyandrogens were significantly elevated in women with PCOS compared to age matched controls, controlling for age and BMI (p < 0.01 for all). When considered together, the four 11-oxyandrogens were more predictive of PCOS compared to testosterone and androstenedione. When all androgens were considered individually, 11-ketoandrostenedione was the most predictive of PCOS. Of the six androgens studied, 11-ketotestosterone was the only androgen that demonstrated a weak association with hirsutism score (r = 0.17; p = 0.07) within the PCOS group.

conclusion11-oxyandrogens were statistically higher in women with PCOS and may serve as better predictors of PCOS than testosterone and androstenedione.

Indexed as

AndrogensHyperandrogenismPolycystic Ovary SyndromeTestosteroneAdolescentAdultAndrostenedioneBiomarkersCase-Control StudiesFemaleHumansPredictive Value of TestsYoung Adult11-ketotestosteroneAndrogensAndrostenedioneBiomarkersTestosterone11‐ketotestosterone11‐oxygenated C19 steroidsandrogenshyperandrogenismpolycystic ovary syndrome

Identifiers

PMID39815717
PMCPMC11735743

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.