Evidence map›Paper›PMID 39815688›Full record

SynthesisJMIR public health and surveillance2025

Availability and Key Characteristics of National Early Warning Systems for Emerging Profiles of Antimicrobial Resistance in High-Income Countries: Systematic Review.

Jessica Iera, Claudia Isonne, Chiara Seghieri, Lara Tavoschi, Mariateresa Ceparano, Antonio Sciurti, Alessia D'Alisera, Monica Sane Schepisi, Giuseppe Migliara, Carolina Marzuillo and 3 more

Abstract readSystematic Review
In one paragraph

Synthesis in JMIR public health and surveillance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jessica IeraDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0009-0003-9257-2136
Claudia IsonneDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-1002-9133
Chiara SeghieriDepartment EMbeDS, Sant'Anna School of Advanced Studies, Management and Health Laboratory, Institute of Management, Pisa, Italy.ORCID 0000-0002-3910-7775
Lara TavoschiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.ORCID 0000-0002-2217-4664
Mariateresa CeparanoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-8304-365X
Antonio SciurtiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0009-0001-3140-7343
Alessia D'AliseraItalian Ministry of Health, General Directorate for Health Prevention, Rome, Italy.ORCID 0009-0003-4267-461X
Monica Sane SchepisiItalian Ministry of Health, General Directorate for Health Prevention, Rome, Italy.ORCID 0009-0009-7375-1431
Giuseppe MigliaraDepartment of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy.ORCID 0000-0002-4573-6025
Carolina MarzuilloDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-7299-5727
Paolo VillariDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-3139-0668
Fortunato D'AnconaDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0002-9855-2924
Valentina BaccoliniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-7873-7817

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The World Health Organization (WHO) recently advocated an urgent need for implementing national surveillance systems for the timely detection and reporting of emerging antimicrobial resistance (AMR). However, public information on the existing national early warning systems (EWSs) is often incomplete, and a comprehensive overview on this topic is currently lacking. Objective: This review aimed to map the availability of EWSs for emerging AMR in high-income countries and describe their main characteristics. Methods: A systematic review was performed on bibliographic databases, and a targeted search was conducted on national websites. Any article, report, or web page describing national EWSs in high-income countries was eligible for inclusion. EWSs were identified considering the emerging AMR-reporting WHO framework. Results: We identified 7 national EWSs from 72 high-income countries: 2 in the East Asia and Pacific Region (Australia and Japan), 3 in Europe and Central Asia (France, Sweden, and the United Kingdom), and 2 in North America (the United States and Canada). The systems were established quite recently; in most cases, they covered both community and hospital settings, but their main characteristics varied widely across countries in terms of the organization and microorganisms under surveillance, with also different definitions of emerging AMR and alert functioning. A formal system assessment was available only in Australia. Conclusions: A broader implementation and investment of national surveillance systems for the early detection of emerging AMR are still needed to establish EWSs in countries and regions lacking such capabilities. More standardized data collection and reporting are also advisable to improve cooperation on a global scale. Further research is required to provide an in-depth analysis of EWSs, as this study is limited to publicly available data in high-income countries.

Indexed as

Developed CountriesDrug Resistance, MicrobialHumansantimicrobial resistanceearly warning systememerging AMRhigh-income countriessurveillance

Identifiers

PMID39815688
PMCPMC11753579

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.