Evidence map›Paper›PMID 39815634›Full record

ArticleJournal of immunotoxicology2024

Anti-microbial cetylpyridinium chloride suppresses mast cell function by targeting tyrosine phosphorylation of Syk kinase.

Bright Obeng, Lucas J Bennett, Bailey E West, Dylan J Wagner, Patrick J Fleming, Morgan N Tasker, Madeleine K Lorenger, Dorothy R Smith, Tetiana Systuk, Sydni M Plummer and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunotoxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Bright ObengDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Lucas J BennettDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Bailey E WestDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Dylan J WagnerDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Patrick J FlemingDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Morgan N TaskerDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Madeleine K LorengerDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Dorothy R SmithDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Tetiana SystukDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Sydni M PlummerDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Jeongwon EomDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Marissa D PaineDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Collin T FrangosDepartment of Biology, University of Maine Augusta, Augusta, Maine, USA.
Michael P WilczekDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Juyoung K ShimDepartment of Biology, University of Maine Augusta, Augusta, Maine, USA.
Melissa S MaginnisDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Julie A GosseDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Mechanisms of cetylpyridinium chloride inhibition of immune cell functionR15ES034567 · NIEHS · UNIVERSITY OF MAINE ORONO · PI GOSSE, JULIE ANN · 2022 to 2022
$426k
NIEHS NIH HHS R15 ES034567NIGMS NIH HHS P20 GM103423
6 · The paper itself

Abstract

Cetylpyridinium chloride (CPC) is a quaternary ammonium antimicrobial used in numerous personal care products, human food, cosmetic products, and cleaning solutions. Yet, there is minimal published data on CPC effects on eukaryotes, immune signaling, and human health. Previously, it was shown that low-micromolar CPC inhibits rat mast cell function by inhibiting antigen (Ag)-stimulated Ca

Indexed as

CetylpyridiniumMast CellsSyk KinaseAnimalsCell DegranulationCell LineHumansPhosphorylationRatsSignal TransductionTyrosineCetylpyridiniumSyk KinaseSYK protein, humanTyrosinecetylpyridinium chlorideLATLynMast cellSyk kinasetyrosine phosphorylation

Identifiers

PMID39815634
PMCPMC11827644

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.