Evidence map›Paper›PMID 39815459›Full record

ReviewMedical physics2025

AAPM Task Group Report 274: Fluence rate dosimetry for photodynamic therapy (PDT).

Timothy C Zhu, Brian W Pogue, Andreea Dimofte, Jarod C Finlay, Lothar Lilge, Ulas Sunar, Charles B Simone, Robert L P van Veen

Abstract readReview
In one paragraph

Review in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Timothy C ZhuUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Brian W PogueUniversity of Wisconsin, Madison, Wisconsin, USA.
Andreea DimofteUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jarod C FinlayUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Lothar LilgeUniversity of Toronto and University Health Network, Toronto, Ontario, Canada.
Ulas SunarStony Brook University, Stony Brook, New York, USA.
Charles B SimoneNew York Proton Center, New York, New York, USA.
Robert L P van VeenNetherlands Cancer Institute - Antoni van Leeuwenhoek hospital, NKI-AvL, Amsterdam, Netherlands.

Funding

Optimizing singlet oxygen dosimetry for photodynamic therapy (PDT)R01EB032821 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI HADFIELD, ROBERT HUGH, ZHU, TIMOTHY C. · 2022 to 2025
$2.4M
In situ PEDSy and light delivery platform for Intracavitory Photodynamic TherapyR01EB028778 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI POTASEK, MARY, ZHU, TIMOTHY C. · 2020 to 2023
$2.2M
Chip-scale fT/cm/Hz^(1/2) optical magnetic gradiometry for gradient magnetoencephalography imaging at room temperatureR21EB026778 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, CHEE WEI · 2018 to 2020
$535k
NIBIB NIH HHS R01 EB028778NIBIB NIH HHS R01 EB032821NIBIB NIH HHS R21 EB026778
6 · The paper itself

Abstract

Photodynamic therapy (PDT) is a treatment modality clinically approved for several oncologic indications, including esophageal and endobronchial cancers, precancerous conditions including Barrett's esophagus and actinic keratosis, and benign conditions like age-related macular degeneration. While it is currently clinically underused, PDT is an area of significant research interest. Because PDT relies on the absorption of light energy by intrinsic or administered absorbers, the dosimetric quantity of interest is the absorbed energy per unit mass of tissue, proportional to the fluence rate of light in tissue. It has been demonstrated that the fluence rate at the tissue surface may differ significantly from the incident irradiance of light because of multiple scattering and absorption, both of which may vary among patients and tissue types. This report will review the current state-of-the-art fluence rate dosimetry technology. It will describe the two types of detectors currently available for fluence rate measurement, scattering-tip and fluorescence-based detectors, and review their principles of operation. The report will recommend strategies to establish calibration and quality assurance procedures for clinical fluence rate dosimetry equipment, and it will establish guidelines for clinical implementation of fluence rate dosimetry.

Indexed as

PhotochemotherapyRadiometryHumansin vivo dosimetrylight fluencephotodynamic therapyTG274

Identifiers

PMID39815459
PMCPMC11882379

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.