ArticleNeurological research and practice2025
Increase of nitrous oxide-induced neurological disorders - a German multicenter experience.
Article in Neurological research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Review
- Response to "Acute myeloneuropathy after nitrous oxide use: multimodal diagnostic insights".Neurological research and practice · 2025Article
- Acute myeloneuropathy after nitrous oxide use: multimodal diagnostic insights : Response to research article: increase of nitrous oxide-induced neurological disorders - a German multicenter experience by Meißner et al.Neurological research and practice · 2025Article
- Nitrous oxide (N2O) recreational use is increasing across Germany - a survey of the German neurological society among practicing neurologists.Neurological research and practice · 2025Article
- Article
- Neurological disorders caused by recreational use of nitrous oxide-a retrospective study from a German metropolitan area and review of the literature.Neurological research and practice · 2025Article
- Nitrous oxide use and psychiatric disorders: a retrospective clinical cohort study on prevalence and patterns.Frontiers in psychiatry · 2025Article
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Authors and funding
11 authors.
Funding
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Abstract
backgroundNitrous oxide (N₂O), commonly known as laughing gas, is widely recognized for its anesthetic and analgesic effects, and is frequently used in medical contexts. However, its misuse can lead to significant neurological complications, which are often under-recognized in clinical practice. Recent data on such cases in Germany are rare. We here report the spectrum of neurological complications associated with the recreational use of N₂O, as encountered in German neurology centers.
methodsWe retrospectively analyzed of 23 cases presenting with neurological symptoms following N₂O abuse between July 2020 and August 2024 across five neurology departments in Germany. Data were collected on patient demographics, clinical manifestations, diagnostic findings, and treatment approaches.
resultsOver the last four years the number of cases increased. Clinical presentations primarily included neuropathy, found in all patients, along with myelopathy. The most common symptoms were sensory loss, ataxia, and motor deficits.
conclusionOur data suggest that N₂O abuse is on the rise in Germany. Further initiatives are warranted to raise awareness among users, healthcare and professionals.
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