Evidence map›Paper›PMID 39815334›Full record

ArticleJournal of neuroengineering and rehabilitation2025

Should you hold onto the treadmill handrails or not? Cortical evidence at different walking speeds.

Monica Biggio, Costanza Iester, Davide Cattaneo, Simone Cutini, Ambra Bisio, Ludovico Pedullà, Alessandro Torchio, Marco Bove, Laura Bonzano

Abstract read
In one paragraph

Article in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Monica BiggioDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Costanza IesterDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Davide CattaneoIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Simone CutiniDepartment of Developmental and Social Psychology, University of Padova, Padua, Italy.
Ambra BisioDepartment of Experimental Medicine, Section of Human Physiology, University of Genoa, Viale Benedetto XV 3, 16132, Genoa, Italy.
Ludovico PedullàItalian Multiple Sclerosis Foundation, Scientific Research Area, Genoa, Italy.
Alessandro TorchioIRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.
Marco BoveDepartment of Experimental Medicine, Section of Human Physiology, University of Genoa, Viale Benedetto XV 3, 16132, Genoa, Italy. marco.bove@unige.it.
Laura BonzanoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.

Funding

Italian Multiple Sclerosis Foundation (FISM) Grant 2022/R-Multi/021
6 · The paper itself

Abstract

backgroundTreadmill-based gait training is part of rehabilitation programs focused on walking abilities. The use of handrails embedded in treadmill systems is debated, and current literature only explores the issue from a behavioral perspective.

methodsWe examined the cortical correlates of treadmill walking in healthy participants using functional near-infrared spectroscopy. We investigated whether the utilization of treadmill handrails at varying walking speeds could affect cortical activation associated with the task, and we evaluated potential differences in task-based functional connectivity across the various walking conditions.

resultsSignificant differences in cortical activation were found between the two walking speeds (3 and 5 km/h) in the unsupported condition; these differences were reduced when using the handrails. Specifically, cortical activation was significantly higher when the participants swung their arms freely while walking at a speed of 5 compared to 3 km/h in several Brodmann's Areas (BA): left BA10, BA3 and BA39, and right BA10, BA9, BA8, BA3, and BA40. No significant differences were found when participants were holding onto the handrails. A significant difference was found in the left BA40 between the two speeds, regardless of whether the participants were holding onto the handrails. Furthermore, at the higher speed and without the use of handrails, a wider pattern of task-based functional connectivity was observed, with significantly stronger connectivity between the left BA10 and BA40.

conclusionsWe suggest that speed and handrails use play a role in walking cortical activity patterns, therefore they are key ingredients to take into account when planning a rehabilitation program.

Indexed as

Cerebral CortexExercise TestWalkingWalking SpeedAdultFemaleHumansMaleSpectroscopy, Near-InfraredYoung AdultFunctional near-infrared spectroscopyHaptic contactTreadmillWalking speed

Identifiers

PMID39815334
PMCPMC11736955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.