ArticleBMC infectious diseases2025
Combined detection of monocyte distribution width and procalcitonin for diagnosing and prognosing neonatal sepsis.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Insights into the mechanism of intestinal flora imbalance and immune disorder in co-morbidity of pneumonia and diarrhea in children.Frontiers in pediatrics · 2026Review
- Prevalence and risk factors for neonatal sepsis among very preterm infants in China: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Diagnostic Utility of Monocyte Distribution Width for Early Sepsis Detection in Cancer-Enriched Emergency Cohort.Journal of clinical medicine · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundTo assess the value of combined Monocyte Distribution Width (MDW) and Procalcitonin (PCT) detection in diagnosing and predicting neonatal sepsis outcomes.
methodsThis retrospective study, conducted from January 2022 to December 2023.A retrospective analysis of 39 neonatal sepsis and 30 non-infectious systemic inflammatory response syndrome (SIRS) cases was conducted. MDW, PCT, and CRP levels were compared. Relationships between variables were analyzed with Pearson correlation and Cox regression models; diagnostic performance was assessed using ROC curves.
resultsMDW, PCT, and CRP were significantly elevated in sepsis cases (p < 0.001). In non-survivors, MDW was higher and correlated with CRP, PCT, and SNAP scores. MDW was identified as an independent predictor of 28-day mortality. Optimal MDW, PCT, and CRP cut-offs (21.3, 1.23 ng/ml, 32.8 mg/L) achieved AUCs of 0.80, 0.84, and 0.60, respectively. Combined MDW/PCT detection achieved an AUC of 0.90 with 88.2% sensitivity and 88.7% specificity.
conclusionMDW, especially when combined with PCT, improves diagnostic accuracy for neonatal sepsis management.
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