ArticleBMC infectious diseases2025
Identifying plasma exosome antigens as a potential diagnostic biomarker for tuberculosis disease.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Role of Exosomes During Mycobacterium Tuberculosis Infection: A Double-Edged Sword.Biomedicines · 2026Review
- Bacterial extracellular vesicles: emerging players in antimicrobial resistance and clinical translation.Molecular biology reports · 2026Review
- Evaluating Variability in Extracellular Vesicle Characterization Across Measurement Techniques.Journal of extracellular biology · 2026Article
- Extracellular Vesicles of Mycobacterium tuberculosis Serve as a Virulence Factor - Current Research Applications.Current microbiology · 2026Review
- Tuberculosis Patients' Serum Extracellular Vesicles Induce Relevant Immune Responses for Initial Defense Against BCG in Mice.Microorganisms · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundExosome is a small extracellular vesicle with a diameter of 30 to 150 nm that is secreted by cells. Mtb and other bacteria can also secrete extracellular vesicles, which carry characteristics and information about the pathogen. Here, we compare the concentration of exosomes and the Mtb antigen in exosomes of tuberculosis patients aiming to evaluate whether exosomes can be used as diagnostic markers of tuberculosis at different stages.
methodsPlasma exosomes were extracted from healthy individuals, the patients with active TB and latent TB, Rehabilitation patients. The concentration and diameter of exosomes from different groups were detected using NTA. The antigen Ag85A, MPT64, CFP-10 of Mtb in exosomes was detected by ELISA. The area under the curve (AUC) was used to model the associations between exosomal Mtb Antigens and tuberculosis.
resultsWe found that MPT64, Ag85A and CFP-10 levels were significantly higher in active and latent patients than in healthy and recovered patients. And he results shown the AUC for patients with active TB was 0.97 for MPT64, 1.0 for Ag85A, and 0.94 for CFP-10; for patients with latent TB, the AUC was 0.86 for MPT64, 0.98 for Ag85A, and 0.83 for CFP-10.
conclusionLevels of MPT64, Ag85A and CFP-10 were significantly up-regulated in plasma exosomes from TB patients and latent patients, and the AUC values of all three antigens predicting TB were higher than 0.9. This finding suggests that the three Mtb antigens in plasma exosomes were reliable diagnostic markers for TB.
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