Evidence map›Paper›PMID 39815142›Full record

ArticleJournal of fluorescence2025

Photophysical Properties, Fluorescence Quenching of Metformin Hydrochloride by Caffeine, and its Docking with the AMP-activated protein kinase receptor.

Semahegn Asemare, Abebe Belay, Alemu Kebede, Umer Sherefedin, T Gurumurthi, Tesfaye Feyisa

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Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Semahegn AsemareDepartment of Applied Physics, School of Applied Natural Sciences, Adama Science and Technology University, PO Box 1888, Adama, Ethiopia. semahegnasemare4@gmail.com.
Abebe BelayDepartment of Applied Physics, School of Applied Natural Sciences, Adama Science and Technology University, PO Box 1888, Adama, Ethiopia.
Alemu KebedeDepartment of Applied Physics, School of Applied Natural Sciences, Adama Science and Technology University, PO Box 1888, Adama, Ethiopia.
Umer SherefedinDepartment of Applied Physics, School of Applied Natural Sciences, Adama Science and Technology University, PO Box 1888, Adama, Ethiopia.
T GurumurthiDepartment of Applied Physics, School of Applied Natural Sciences, Adama Science and Technology University, PO Box 1888, Adama, Ethiopia.
Tesfaye FeyisaDepartment of Applied Physics, School of Applied Natural Sciences, Adama Science and Technology University, PO Box 1888, Adama, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this research, the photophysical properties of metformin hydrochloride (MF-HCl) were studied using spectroscopic and molecular docking techniques. The interaction between metformin hydrochloride and caffeine is essential for understanding the pharmacokinetics of metformin, particularly in populations with high caffeine consumption. Metformin is a first-line medication for managing type 2 diabetes, while caffeine is a widely consumed dietary stimulant. Knowing how caffeine may affect the action of metformin is crucial for effective diabetes management. The spectroscopic techniques results showed that the photophysical properties (fluorescence quantum yields, lifetime, radiative, and non-radiative decay) of the drug are influenced by solvent polarity and drug concentration. The binding mechanism of metformin hydrochloride-caffeine (MF-HCl-CAF) was identified through the fluorescence quenching method. The quenching of drugs induced by caffeine is due to ground state complex formation. The binding occurs due to hydrogen bonds and Van der Waals forces in the reaction. The förster resonance energy transfer (FRET) between metformin hydrochloride and caffeine was also calculated using flourtools.com software. The threshold distance (R

Indexed as

AMP-Activated Protein KinasesCaffeineMetforminMolecular Docking SimulationFluorescenceFluorescence Resonance Energy TransferSpectrometry, FluorescenceAMP-Activated Protein KinasesCaffeineMetforminCaffeineFluorescence quenchingMetformin hydrochlorideMolecular dockingPhotophysical properties

Identifiers

PMID39815142

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.