Evidence map›Paper›PMID 39815107›Full record

ArticleNeurocritical care2025

Noninvasive Vagus Nerve Stimulation Protects Neurons in the Perihematomal Region and Improves the Outcomes in a Rat Model of Intracerebral Hemorrhage.

Eder Cáceres, Pascal Salazar, Satoka Shidoh, Michael J Ortiz, Denis E Bragin, Fazle Kibria, Afshin A Divani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocritical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eder CáceresUnisabana Center for Translational Science, School of Medicine, Universidad de La Sabana, Chía, Colombia.
Pascal SalazarCanon Medical Informatics, Inc, Minnetonka, MN, USA.
Satoka ShidohDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Michael J OrtizDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Denis E BraginDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Fazle KibriaLovelace Biomedical Research Institute, Albuquerque, NM, USA.
Afshin A DivaniDepartment of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. adivani@gmail.com.ORCID 0000-0001-8448-0758

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Brain Injury Treatment by Modulation of Hemodynamics With Blood Soluble Drag Reducing MoleculesR01NS112808 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2019 to 2023
$2.1M
Stroke Treatment by Modulation of Hemodynamics with Drag Reducing MoleculesR21NS091600 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2015 to 2016
$423k
Noninvasive Vagus Nerve Stimulation for Treatment of Brain Injury (nVNS-TBI) in RatsR21NS130423 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DIVANI, AFSHIN ANDRE · 2022 to 2022
$419k
NIGMS NIH HHS P20 GM109089NINDS NIH HHS 1R21NS130423-01NINDS NIH HHS R01 NS112808NINDS NIH HHS R21 NS091600NINDS NIH HHS R21 NS130423
6 · The paper itself

Abstract

backgroundIntracranial hemorrhage (ICH) is a devastating stroke subtype with a high rate of mortality and disability. Therapeutic options available are primarily limited to supportive care and blood pressure control, whereas the surgical approach remains controversial. In this study, we explored the effects of noninvasive vagus nerve stimulation (nVNS) on hematoma volume and outcome in a rat model of collagenase-induced ICH.

methodsAdult male Wistar rats were randomized into two study groups: (1) ICH-treated (rats treated with five 2-min nVNS) and (2) ICH-control (ICH with sham nVNS). Each group received either a 0.1-U or a 0.2-U collagenase dose. After assessing neurological function, rats were euthanized at 24 h for spectrophotometric hemoglobin assay, hematoma volume measurements, and histological studies.

resultsThe ICH-treated group that received the 0.1-U collagenase dose demonstrated significantly smaller hematoma volume and improved motor function compared with the ICH-control with the same dose. Furthermore, the pooled data for the ICH-treated groups (both 0.1 U and 0.2 U of collagenase) revealed a reduction in neuronal loss in the perihematomal region in the histopathological studies. This effect was not significant for the group that received a 0.2-Ucollagenase dose.

conclusionsnVNS therapy in acute settings may provide a neuroprotective effect and limit hematoma expansion in smaller volumes, improving neurological function post-ICH.

Indexed as

Cerebral HemorrhageHematomaNeuronsVagus Nerve StimulationAnimalsCollagenasesDisease Models, AnimalMaleRandom AllocationRatsRats, WistarCollagenasesBrain edemaHematoma volumeIntracerebral hemorrhageNeurobehavioral outcomesNeuromodulationVagus nerve stimulation

Identifiers

PMID39815107
PMCPMC12459854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.