Evidence map›Paper›PMID 39815063›Full record

ArticleNature materials2025

Zinc nanoparticles from oral supplements accumulate in renal tumours and stimulate antitumour immune responses.

Xin Zeng, Zhenzhu Wang, An Zhao, Yiqi Wu, Zongping Wang, Aiwen Wu, Qing Wang, Xin Xia, Xichen Chen, Wene Zhao and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Xin Zeng *Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, China.
Zhenzhu Wang *Department of Cell Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
An Zhao *Zhejiang Cancer Institute, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, China. zhaoan@zjcc.org.cn.ORCID 0000-0001-9630-0793
Yiqi Wu *Department of Cell Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
Zongping WangZhejiang Cancer Institute, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, China.
Aiwen WuWomen's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, China.ORCID 0009-0006-0814-5265
Qing WangWomen's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, China.
Xin XiaDepartment of Human Anatomy, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
Xichen ChenAnalytical and Testing Center, Nanjing Medical University, Nanjing, China.ORCID 0009-0003-6489-2159
Wene ZhaoAnalytical and Testing Center, Nanjing Medical University, Nanjing, China.
Bozhao LiCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China, Beijing, China.
Zefang LuCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China, Beijing, China.
Qiaoli LvJiangxi Key Laboratory of Translational Cancer Research, Jiangxi Cancer Hospital of Nanchang University, Nanchang, China.
Guorong LiDepartment of Digestive Surgery and Urology, North Hospital, CHU Saint-Etienne, Saint-Etienne, France.
Zhixiang ZuoState Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Fengrui WuAnhui Province Key Laboratory of Environmental Hormone and Reproduction, Fuyang Normal University, Fuyang, China.
Yuliang ZhaoCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China, Beijing, China.ORCID 0000-0002-9586-9360
Ting WangDepartment of Cell Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China. wangting@njmu.edu.cn.ORCID 0000-0002-2425-4684
Guangjun NieCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China, Beijing, China. niegj@nanoctr.cn.ORCID 0000-0001-5040-9793
Suping LiCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China, Beijing, China. lisuping@nanoctr.cn.ORCID 0000-0002-0294-8861
Gen ZhangDepartment of Cell Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China. zhanggen@njmu.edu.cn.ORCID 0000-0002-1463-2426

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82073392National Natural Science Foundation of China (National Science Foundation of China) 82472141
6 · The paper itself

Abstract

A successful therapeutic outcome in the treatment of solid tumours requires efficient intratumoural drug accumulation and retention. Here we demonstrate that zinc gluconate in oral supplements assembles with plasma proteins to form ZnO nanoparticles that selectively accumulate into papillary Caki-2 renal tumours and promote the recruitment of dendritic cells and cytotoxic CD8

Indexed as

Antineoplastic AgentsDietary SupplementsKidney NeoplasmsMetal NanoparticlesNanoparticlesZincZinc OxideAdministration, OralAnimalsCell Line, TumorFemaleHumansMetallothioneinMiceRabbitsAntineoplastic AgentsMetallothioneinZincZinc Oxide

Identifiers

PMID39815063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.