Evidence map›Paper›PMID 39815039›Full record

ArticleScientific reports2025

Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study.

Shuhei Suzuki, Hiromitsu Negoro, Masashi Kubota, Takayuki Sumiyoshi, Ryoichi Saito, Tomoya Okuno, Takehiko Segawa, Shigeki Fukuzawa, Hiroyuki Onishi, Kodai Hattahara and 9 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shuhei SuzukiDepartment of Urology, University of Tsukuba, Ibaraki, Japan.
Hiromitsu NegoroDepartment of Urology, University of Tsukuba, Ibaraki, Japan.
Masashi KubotaDepartment of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Takayuki SumiyoshiDepartment of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Ryoichi SaitoDepartment of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Tomoya OkunoDepartment of Urology and Retroperitoneal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Takehiko SegawaDepartment of Urology, Kyoto City Hospital, Kyoto, Japan.
Shigeki FukuzawaDepartment of Urology, Shimada General Medical Center, Shizuoka, Japan.
Hiroyuki OnishiDepartment of Urology, Japanese Red Cross Osaka Hospital, Osaka, Japan.
Kodai HattaharaDepartment of Urology, Shiga General Hospital, Shiga, Japan.
Kanji NagahamaDepartment of Urology, Rakuwakai Otowa Hospital, Kyoto, Japan.
Yuya SekineDepartment of Urology, Akita University Graduate School of Medicine, Akita, Japan.
Ryoma KurahashiDepartment of Urology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Kimihiro ShimataniDepartment of Urology, Hyogo Medical University, Hyogo, Japan.
Atsuro SawadaDepartment of Urology, Miyazaki University, Miyazaki, Japan.
Shusuke AkamatsuDepartment of Urology, Nagoya University, Aichi, Japan.
Hiroyuki NishiyamaDepartment of Urology, University of Tsukuba, Ibaraki, Japan.
Takayuki GotoDepartment of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. goto@kuhp.kyoto-u.ac.jp.
Takashi KobayashiDepartment of Urology, Kyoto University School of Medicine, 54 Shougoinkawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan. selecao@kuhp.kyoto-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the impact of aspirin on the biochemical recurrence (BCR) rate following robot-assisted radical prostatectomy (RARP) in patients. A database search identified patients who underwent RARP for pT2-3N0M0 disease at any of 25 centers between 2011 and 2022, categorized into aspirin (n = 350) and control groups (n = 5857). Adjustment by 1:1 propensity score matching (PSM) and Mahalanobis distance matching (MDM) created 350 matched pairs. The effect of aspirin on the BCR rate was evaluated by analysis of BCR-free survival. After PSM and MDM, the 3-year BCR-free rate was significantly better in the aspirin group (85.0%, 95% confidence interval [CI] 80.8-89.4) than in the control group (PSM, 74.5%, 95% CI 66.5-83.5, p = 0.021; MDM, 74.7%, 95% CI 66.3-84.3, p = 0.037). In the analysis of high-risk subgroups, patients in the aspirin group with an ISUP (International Society of Urological Pathology) grade ≥ 4 had a significantly lower recurrence rate in both matched groups (PSM, hazard ratio 0.44, 95% CI 0.22-0.88; MDM, hazard ratio 0.45, 95% CI 0.23-0.90). In conclusion, this study suggests that aspirin could enhance BCR-free survival post-RARP, especially in patients with higher ISUP grades.

Indexed as

AspirinNeoplasm Recurrence, LocalProstatectomyProstatic NeoplasmsRobotic Surgical ProceduresAgedDisease-Free SurvivalHumansMaleMiddle AgedPropensity ScoreProstate-Specific AntigenRetrospective StudiesAspirinProstate-Specific AntigenAspirinBiochemical recurrenceProstate cancerRobot-assisted laparoscopic radical prostatectomySurvival rate

Identifiers

PMID39815039
PMCPMC11736026

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.