ArticleAbdominal radiology (New York)2025
A predictive clinical-radiomics nomogram for early diagnosis of mesenteric arterial embolism based on non-contrast CT and biomarkers.
Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
purposeMesenteric artery embolism (MAE) is a relatively uncommon abdominal surgical emergency, but it can lead to catastrophic clinical outcomes if the diagnosis is delayed. This study aims to build a prediction model of clinical-radiomics nomogram for early diagnosis of MAE based on non-contrast computed tomography (CT) and biomarkers.
methodIn this retrospective study, a total of 364 patients confirmed as MAE (n = 131) or non-MAE (n = 233) who were randomly divided into a training cohort (70%) and a validation cohort (30%). In the training cohort, the minimum redundancy maximum relevance (mRMR) and the least absolute shrinkage and selection operator (LASSO) algorithms were used to select optimal radiomics features from non-contrast CT images for calculating Radscore which was utilized to establish the radiomics model. Logistic regression analysis was performed to screen clinical factors, and then generate the clinical model. A predictive nomogram model was built using Radscore and the selected clinical risk factors, which was evaluated through the receiver operating characteristic (ROC) curve, calibration curve and decision curve analysis (DCA).
resultsThirteen radiomics features were chosen to calculate Radscore. Age, white blood cell (WBC) count, creatine kinase (CK) and D-dimer were determined as the independent clinical factors. The clinical-radiomics nomogram model showed the best performance in training cohort. The nomogram model was with higher area under curve (AUC) value of 0.93, compared to radiomics model with AUC value of 0.90 or clinical model with AUC value of 0.78 in the validation cohort. The calibration curve showed that nomogram model achieved a good fit in both cohorts (P = 0.59 and 0.92, respectively). The DCA indicated that nomogram model was significantly favorable for clinical usefulness of MAE diagnosis.
conclusionsThe nomogram provides an effective tool for the early diagnosis of MAE, which may play a crucial role in shortening the time for therapeutic decision-making, thereby reducing the risk of intestinal necrosis and death.
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