ArticleSkeletal radiology2025
Paravertebral crystal deposition disease: a retrospective study of clinical presentation, prevalence, and CT imaging findings.
Article in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesParavertebral crystal deposition disease, characterized by the deposition of crystals around the vertebral bodies leading to acute inflammation and pain, is a condition that remains largely unrecognized. This study aims to elucidate the prevalence, clinical features, and CT findings associated with this disease.
methodsWe retrospectively analyzed 14,839 consecutive patients who underwent chest and/or abdominal CT (September 2017 to September 2024) owing to chest, abdominal, or back pain. Cases demonstrating paravertebral calcification with a surrounding soft tissue density of ≥ 5 mm were identified and further evaluated.
resultsTwenty-four cases of paravertebral crystal deposition disease were identified, with a prevalence of 0.16% (95% CI: 0.10, 0.24). The mean age was 46.2 years, with a female predominance (n = 15, 63%). Back pain was the most common presenting symptom (n = 15, 63%). Calcifications were primarily located at the lower thoracic and upper lumbar spine (Th6/7-L1/2) in 18 cases (75%) and in the anterior median to anterior right region of the vertebral body in 21 cases (86%). Mean of maximum CT values of the crystal deposition was approximately 800 HU; in follow-up cases, the depositions either resolved or exhibited morphological changes.
conclusionsThis study adds to the current knowledge base by identifying a 0.16% prevalence of paravertebral crystal deposition disease in patients with torso pain-often overlooked in clinical practice, primarily affecting middle-aged women. CT imaging shows calcifications mainly in the lower thoracic and upper lumbar spine. Considering this self-limiting disease in differential diagnoses can improve diagnostic accuracy and patient management.
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