Evidence map›Paper›PMID 39814952›Full record

Trial reportSurgical endoscopy2025

Preservation of inferior mesenteric artery reduces short- and long-term defecatory dysfunction after laparoscopic colorectal resection for diverticular disease: An RCT.

Francesco Saverio Mari, Lucio Chiarini, Laura Trampetti, Chiara Savina, Federica Cosmi, Arianna Cicolani, Marcello Gasparrini, Antonio Brescia

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06506552 (Inferior Mesenteric Artery Preservation in Laparoscopic Colorectal Resection for Diverticular Disease; Short and Long Term Effects in Defecatory Function), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06506552 nacompletednot on this map

Inferior Mesenteric Artery Preservation in Laparoscopic Colorectal Resection for Diverticular Disease; Short and Long Term Effects in Defecatory Function

TypeinterventionalSponsorUniversity of Roma La SapienzaRan2012 to 2024Enrolled300ConditionsColonic Diverticuar Disease, Defecatory Functions, Fecal Incontinence, ConstipationArmsIMA preserving, IMA sectioning
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesco Saverio MariDepartment of Surgery, St. Maria Goretti Hospital, Latina, Italy. francescosaverio.mari@gmail.com.ORCID 0000-0002-2662-823X
Lucio ChiariniDepartment of Surgery, St. Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Laura TrampettiDepartment of Surgery, St. Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Chiara SavinaDepartment of Surgery, St. Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Federica CosmiDepartment of Surgery, St. Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Arianna CicolaniDepartment of Surgery, St. Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Marcello GasparriniDepartment of Surgery, St. Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Antonio BresciaDepartment of Surgery, St. Andrea Hospital, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe quality of life after surgery for diverticular disease is mainly linked to the presence and severity of postoperative defecatory disorders. These symptoms are frequently related to the sigmoid and rectal denervation following the arterial ligation. The preservation of Inferior Mesenteric Artery performing colorectal resections seems to reduce denervation, which led to a better defecatory function. This study aimed to assessing the efficacy of inferior mesenteric artery preservation following colonic resections for diverticular disease in terms of reduced defecatory disorders and improved quality of life.

methodsThis is a prospective randomized controlled trial entirely conducted at St. Maria Goretti and St. Andrea Hospitals. Between January 2012 and January 2018 each patient scheduled for sigmoidectomy, left colonic or rectal resection for diverticular disease were included in the study and randomly divided in two groups. Colorectal resections were performed either preserving the inferior mesenteric artery or not. The incurrence of defecatory disorders and their impact on QoL of defecatory disorders were assessed with 6 questionnaires, administered at 6 and12 months and after 6 years from surgery and with an anorectal manometry performed after 6 months and 5 years.

results219 patients were evaluated during the study showing a statistically lower incidence and severity of defecatory disorders in the group of patients whose inferior mesenteric artery was preserved. These defecatory disorders remained stable over the time. The study showed a statistically better quality of life in patients who experienced less defecatory disorders.

conclusionInferior Mesenteric Artery preserving in colonic resection for diverticular disease allows to improve defecatory function by reducing the denervated colonic tract. This led to better quality of life and less impairment of daily activities also after 6 years from surgery. The study was registered in ClinicalTrials.gov with number NCT06506552.

Indexed as

ColectomyDiverticular DiseasesLaparoscopyMesenteric Artery, InferiorOrgan Sparing TreatmentsPostoperative ComplicationsAgedColon, SigmoidDefecationFemaleHumansMaleMiddle AgedProspective StudiesQuality of LifeRectumConstipationDiverticular diseaseIncontinenceLeft hemicolectomyLower anterior resection syndromePostoperative defecatory disordersRectal resectionSigmoidectomy

Identifiers

PMID39814952

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.