Evidence map›Paper›PMID 39814942›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

"They knew the same struggles": perceptions of a group coping skills intervention in patients with chronic graft-versus-host disease.

Joely A Centracchio, Daniel G Yang, Annemarie D Jagielo, Joseph A Greer, Areej El-Jawahri, Lara Traeger, Ashley M Nelson

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04479995 (Multidisciplinary Intervention to Promote Medical Adherence and Coping in Patients With Moderate to Severe Chronic Graft-Versus-Host Disease), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04479995 naactive not recruitingnot on this map

Multidisciplinary Intervention to Promote Medical Adherence and Coping in Patients With Moderate to Severe Chronic Graft-Versus-Host Disease (GVHD

TypeinterventionalSponsorMassachusetts General HospitalRan2020 to 2027Enrolled80ConditionsStem Cell Transplant Complications, Graft Vs Host Disease, Coping Skills, Quality of LifeArmsHorizon Program, Usual Care
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joely A CentracchioMassachusetts General Hospital, Boston, MA, USA. jcentracchio@miami.edu.ORCID http://orcid.org/0000-0003-3000-5454
Daniel G YangMassachusetts General Hospital, Boston, MA, USA.
Annemarie D JagieloMassachusetts General Hospital, Boston, MA, USA.
Joseph A GreerMassachusetts General Hospital, Boston, MA, USA.
Areej El-JawahriMassachusetts General Hospital, Boston, MA, USA.
Lara TraegerMassachusetts General Hospital, Boston, MA, USA.
Ashley M NelsonMassachusetts General Hospital, Boston, MA, USA.

Funding

Training in Oncology Population Sciences (TOPS)T32CA092203 · NCI · DANA-FARBER CANCER INST · PI Nancy L Keating, JENNIFER W MACK · 2018 to 2026
$3.7M
Reducing Persistent Fatigue Following Hematopoietic Stem Cell TransplantationK23HL159328 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NELSON, ASHLEY · 2021 to 2025
$870k
Division of Cancer Prevention of the National Cancer Institutes of the National Institutes of Health NCI T32 CA092203NCI NIH HHS T32 CA092203NHLBI NIH HHS K23 HL159328
6 · The paper itself

Abstract

purposeChronic graft-versus-host-disease (cGVHD), an inflammatory condition affecting allogeneic hematopoietic cell transplantation (HCT) survivors, is associated with a range of debilitating physical and psychological sequela. Yet HCT recipients with cGVHD are virtually absent from survivorship intervention research. We conducted a randomized clinical trial to evaluate the feasibility and preliminary efficacy of a multidisciplinary group coping skills intervention (Horizons) tailored to meet these patients' unique needs. For this follow-up qualitative analysis, we evaluated the perceived impact of the Horizons intervention by the group participants.

methodsWe purposefully selected a subset of Horizons participants (n = 19) to complete audio-recorded exit interviews via semi-structured interview guide. We used rapid analysis to characterize participant feedback in three domains: (1) motivations to participate, (2) perceived benefits of participation, and (3) impacts of participation.

resultsFindings highlight participants' motivations to participate centered on desires to connect with others living with cGVHD and to help future patients. Perceived benefits of participation focused on the following categories: (1) connecting with other survivors, (2) learning about cGVHD, and (3) learning coping strategies to manage specific cGVHD symptoms. Impacts of participation on everyday life variably reflected categories of (1) increased sense of empowerment to contact their care team with questions and concerns, (2) increased support and validation in their struggles with cGVHD, and (3) renewed motivation or progress toward personal and health-specific goals.

conclusionStudy findings demonstrate participants' appreciation for a group-based opportunity to connect with others living with cGVHD and strengthen skills for navigating cGVHD challenges. Results support the ongoing need for evidence-based interventions to improve quality of life among HCT survivors.

trial registrationwww. CLINICALTRIALS: gov , identifier NCT04479995. Date of Registration: July 21, 2020.

Indexed as

Adaptation, PsychologicalGraft vs Host DiseaseHematopoietic Stem Cell TransplantationAdultAgedChronic DiseaseCoping SkillsFemaleHumansMaleMiddle AgedMotivationQualitative ResearchCoping skillsGraft vs. host diseaseHematopoietic stem cell transplantationQualitative researchQuality of lifeSelf-management

Identifiers

PMID39814942
PMCPMC11735584

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.