ArticleNature2025
De novo designed proteins neutralize lethal snake venom toxins.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pediatric snakebite in Sub-Saharan Africa: Clinical predictors, outcomes, and gaps in care-A systematic review.PLoS neglected tropical diseases · 2026Pooled it
- Global analysis of thermal and chemical denaturation using CheMelt: Thermodynamic dissection of highly thermostable de novo designed proteins.Protein science : a publication of the Protein Society · 2026Article
- Multiobjective VScience advances · 2026Article
- Accelerating protein design by scaling experimental characterization.Nature communications · 2026Article
- Nature's antivenom: Combinations of conserved rattlesnake serum metalloproteinase inhibitors block the lethal action of viper venoms.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Artificial intelligence in drug discovery - what it is, where we stand and the path forward.Nature reviews. Drug discovery · 2026Review
- Article
- RINAMI: Residue-attributed interpretable neural network for predicting absolute folding free energy by merging structure and sequence information.Protein science : a publication of the Protein Society · 2026Article
- Engineering Antivenom: Research Progress and Future Directions in Snakebite Envenoming Therapy.Annals of the New York Academy of Sciences · 2026Review
- Article
- AbioRxiv : the preprint server for biology · 2026Article
- Saxiphilin functions as a toxin sponge protein that counteracts the effects of saxitoxin poisoning.Nature communications · 2026Article
- Artificial intelligence in biologic drug discovery: A review of methodological evolution and therapeutic applications.Acta pharmaceutica Sinica. B · 2026Review
- Degradomics for large-scale mechanistic insights on proteases and proteolysis in human health.The FEBS journal · 2026Review
- Orally available designed miniproteins inhibit enterotoxigenicbioRxiv : the preprint server for biology · 2026Article
- SplitSeek-Pro: accurate prediction of splittable sites on protein structures.Nature communications · 2026Article
- Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection.Nature communications · 2026Article
- Tools For Building Artificial Biological Nanostructures.ACS nano · 2026Review
- How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution.Chemical Society reviews · 2026Review
- Protein design and RNA design: Perspectives.Quantitative biology (Beijing, China) · 2026Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
33 authors.
Susana Vázquez TorresDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Melisa Benard ValleDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0002-0042-6592
Stephen P MackessyDepartment of Biological Sciences, University of Northern Colorado, Greeley, CO, USA.ORCID http://orcid.org/0000-0003-4515-2545
Stefanie K MenziesCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.ORCID http://orcid.org/0000-0002-9273-9296
Nicholas R CasewellCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.ORCID http://orcid.org/0000-0002-8035-4719
Shirin AhmadiDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Nick J BurletDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0009-0002-5099-3971
Edin MuratspahićDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Isaac SappingtonDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Max D OverathDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Esperanza Rivera-de-TorreDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0002-0272-6150
Jann LedergerberDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Andreas H LaustsenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0001-6918-5574
Kim BoddumSophion Bioscience, Ballerup, Denmark.
Asim K BeraDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9473-2912
Alex KangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5487-0499
Evans BrackenbroughDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Iara A CardosoCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.ORCID http://orcid.org/0000-0002-0288-4706
Edouard P CrittendenCentre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.ORCID http://orcid.org/0000-0003-1676-5457
Rebecca J EdgeDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Justin DecarreauDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Robert J RagotteDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Arvind S PillaiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5012-1199
Mohamad AbediDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Hannah L HanDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4787-5168
Stacey R GerbenDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-0313-6248
Analisa MurrayDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1560-6673
Rebecca SkotheimDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0005-0757-8432
Lynda StuartDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Lance StewartDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4264-5125
Thomas J A FryerDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Timothy P JenkinsDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. tpaje@dtu.dk.ORCID http://orcid.org/0000-0003-2979-5663
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID http://orcid.org/0000-0001-7896-6217
Funding
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6MNIGMS NIH HHS P30 GM133893Wellcome Trust
Abstract
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually and causing severe complications and long-lasting disabilities for many more
Indexed as
Drug DesignProtein EngineeringSnake VenomsAnimalsElapid VenomsFemaleHumansMaleMiceModels, MolecularNeurotoxinsProtein StabilitySnake BitesElapid VenomsNeurotoxinsSnake Venoms
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.