Evidence map›Paper›PMID 39814866›Full record

ArticleScientific reports2025

Implications for the diagnosis of aspiration and aspergillosis in critically ill patients with detection of galactomannan in broncho-alveolar lavage fluids.

Simon Dubler, Michael Etringer, Christoph Lichtenstern, Thorsten Brenner, Stefan Zimmermann, Paul Schnitzler, Bettina Budeus, Fabian Rengier, Paulina Kalinowska, Yuan Lih Hoo and 1 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Simon DublerDepartment of Anesthesiology, Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany. simon.dubler@uk-essen.de.
Michael EtringerDepartment of Anesthesiology, Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany.
Christoph LichtensternDepartment of Anesthesiology, Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany.
Thorsten BrennerDepartment of Anaesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg- Essen, 45147, Essen, Germany.
Stefan ZimmermannDivision Bacteriology, Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, 69120, Heidelberg, Germany.
Paul SchnitzlerDepartment of Infectious Diseases, Virology, Heidelberg University Hospital, 69120, Heidelberg, Germany.
Bettina BudeusInstitute of Cell Biology (Cancer Research), University of Duisburg-Essen, 45147, Essen, Germany.
Fabian RengierClinic for Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120, Heidelberg, Germany.
Paulina KalinowskaClinic for Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120, Heidelberg, Germany.
Yuan Lih HooDepartment of Anesthesiology, Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany.
Markus A WeigandDepartment of Anesthesiology, Medical Faculty, Heidelberg University, 69120, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive infections with Aspergillus fumigatus in ICU patients are linked to high morbidity and mortality. Diagnosing invasive pulmonary aspergillosis (IPA) in non-immunosuppressed patients is difficult, as Aspergillus antigen (galactomannan [GM]) may have other causes. This retrospective study analyzed 160 ICU surgical patients with positive GM in broncho-alveolar lavage fluid (BALF), classifying them based on AspICU criteria for suspected IPA (pIPA) or aspiration. Patients with pIPA had higher disease severity than those with aspiration, including higher dialysis rates, organ transplantation, corticosteroid use, and Sequential Organ Failure Assessment (SOFA) score. Aspergillus culture was positive in 47.0% of pIPA cases but only 2.6% of aspiration cases (p < 0.001). SOFA score at first positive GM in BALF independently predicted 28-day mortality. In surgical patients with a positive GM in BALF, aspiration is more likely if there's no corticosteroid therapy, negative Aspergillus culture, and a history of aspiration events. Diagnosis of pIPA requires Aspergillus culture or prior corticosteroid therapy in this cohort of critically ill patients.

Indexed as

Bronchoalveolar Lavage FluidInvasive Pulmonary AspergillosisMannansAdultAgedAspergillus fumigatusCritical IllnessFemaleGalactoseHumansMaleMiddle AgedRetrospective StudiesgalactomannanGalactoseMannansAspergillosisAspergillus spp.Critical illnessIntensive care unitInvasive pulmonary aspergillosisPneumonia

Identifiers

PMID39814866
PMCPMC11735627

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