Evidence map›Paper›PMID 39814759›Full record

ArticleScientific data2025

Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang.

Hyejin Shin, Jihyun Kim, Musun Park, Heeseon Jo, Myunggyo Lee, Seongwon Cha, Haeseung Lee, Sooseong You

Abstract readDataset
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hyejin Shin *Korean Medicine (KM) Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.ORCID http://orcid.org/0000-0001-6497-5067
Jihyun Kim *Korean Medicine (KM) Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.
Musun ParkKM Data Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.ORCID http://orcid.org/0000-0002-5383-5285
Heeseon JoDepartment of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241, Republic of Korea.
Myunggyo LeeDepartment of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241, Republic of Korea.ORCID http://orcid.org/0009-0003-6471-4707
Seongwon ChaKM Data Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.
Haeseung LeeDepartment of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241, Republic of Korea. Haeseung@pusan.ac.kr.ORCID http://orcid.org/0000-0002-9947-4032
Sooseong YouKorean Medicine (KM) Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea. ethink33@kiom.re.kr.ORCID http://orcid.org/0000-0001-6948-892X

Funding

Korea Institute of Oriental Medicine (KIOM) KSN1722122Korea Institute of Oriental Medicine (KIOM) KSN20233305
6 · The paper itself

Abstract

Samul-tang (SM) is a traditional multi-ingredient herbal formula that is widely used in clinical practice for treating female infertility. Despite its known therapeutic benefits, the complexity of its action mechanisms owing to the combination of multiple compounds has limited its research and integration into modern pharmacological science. To address this challenge, we identified 38 herbal compounds as the major ingredients in SM and generated their transcriptome data from aged-mice ovaries by administering these individual compounds. This dataset provides a resource for investigating the action mechanisms of SM and assist in identifying effective combinations of ingredients that can reproduce the therapeutic effects of SM.

Indexed as

AgingDrugs, Chinese HerbalOvaryTranscriptomeAnimalsFemaleGene Expression ProfilingMiceDrugs, Chinese Herbal

Identifiers

PMID39814759
PMCPMC11736141

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.