ArticleNano letters2025
Intramolecular DNA Wheel Construction for Highly Sensitive Electrochemical Detection of miRNA.
Article in Nano letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Self-assembled multifunctional hairpin probe for ultrasensitive and mismatch-selective miRNA detection.Journal of pharmaceutical analysis · 2026Article
- Non-Fullerene Organic Semiconductor ITIC as a Redox Mediator in Electrochemical Glucose Biosensors.Sensors (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate and reliable quantification of disease-related biomolecules is essential for clinical diagnosis. In this study, a novel electrochemical approach is developed based on a target triggered DNA nanostructural switch from a hairpin dimer to a double-stranded wheel. During the process, electrochemical species get closer to the electrode interface, and the multiple intramolecular strand displacements are beneficial to low abundant target analysis. In addition, the use of nicking endonuclease mitigates background interference. This strategy enables highly sensitive and selective quantification of the target miRNA. A linear relationship is established between the peak current intensity and the logarithm of miRNA concentration within the range from 0.1 to 20 fM. This method also demonstrates high accuracy in the analysis of clinical samples, holding great potential for DNA nanotechnology in diagnostic applications.
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Registered trials
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