ArticleThe journal of prevention of Alzheimer's disease2025
Modifiable risk factors for early- and late-onset dementia using the Korean national health insurance service database.
Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identifying risk factors of young-onset dementia and evaluating evidence hierarchy: a meta-analysis and umbrella review.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Age- and sex-specific trends in dementia mortality among people with and without diabetes: a multi-country population-based analysis.Diabetologia · 2026Article
- Environmental Factors and Risk of Early-Onset Dementia: A Population-Based Case-Control Study.Neuroepidemiology · 2025Article
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Authors and funding
4 authors.
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Abstract
backgroundEarly-onset dementia (EOD) and late-onset dementia (LOD) may have distinct modifiable risk-factor profiles.
objectiveTo identify and compare factors associated with EOD and LOD using a nationwide cohort database.
designNationwide two nested case-control studies.
settingWe used the National Health Insurance Service-National Sample Cohort database (2004-2019).
participantsThe initial sample size was 514,866; 5157 EOD and 39,326 LOD cases were matched 1:1 with controls based on age, sex, and the Charlson Comorbidity Index. MEASUREMENTS: Socioeconomic status, residential area, body mass index, alcohol consumption, smoking status, physical activity, blood pressure, and laboratory findings were analyzed. Multivariable logistic regression models were used to identify the risk factors.
resultsHigher socioeconomic status and increased frequency of physical activity were associated with a lower risk of both EOD and LOD. Rural residence, heavy alcohol consumption, and higher fasting blood sugar levels were associated with an increased risk of LOD, although there was no significant association with EOD. Overall, these factors impacted LOD more strongly than EOD. Demographic and lifestyle factors had a greater effect on LOD than blood pressure and relevant laboratory findings.
conclusionModifiable risk factors were associated with LOD and EOD. The influence of some modifiable risk factors was more pronounced in the LOD group than in the EOD group. Identifying modifiable risk factors associated with dementia can aid in the development of preventive strategies, underscoring the clinical importance of our findings.
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