Evidence map›Paper›PMID 39814552›Full record

ArticleLife science alliance2025

UNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemia.

Youhani Samarakoon, Tamas Yelland, Esther Garcia-Gonzalez, Amauri da Silva Justo Junior, Mahnoor Mahmood, Anand Manoharan, Shaun Patterson, Valentina Serafin, Payam A Gammage, Sandra Marmiroli and 3 more

Abstract read
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In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Youhani SamarakoonCRUK Scotland Institute, Glasgow, UK youhani.samarakoon@cruk.cam.ac.uk.ORCID 0000-0002-9845-4232
Tamas YellandCRUK Scotland Institute, Glasgow, UK.
Esther Garcia-GonzalezCentral Laser Facility, Science & Technology Facility Council, The Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Campus, Oxfordshire, UK.ORCID 0000-0002-6424-5379
Amauri da Silva Justo JuniorCRUK Scotland Institute, Glasgow, UK.ORCID 0000-0001-9682-0158
Mahnoor MahmoodCRUK Scotland Institute, Glasgow, UK.
Anand ManoharanSchool of Cancer Sciences, University of Glasgow, Scotland, UK.
Shaun PattersonSchool of Cancer Sciences, University of Glasgow, Scotland, UK.
Valentina SerafinDepartment of Biomedical, Metabolic and Neural Sciences, Cellular Signalling Unit, University of Modena and Reggio Emilia, Modena, Italy.
Payam A GammageCRUK Scotland Institute, Glasgow, UK.
Sandra MarmiroliDepartment of Biomedical, Metabolic and Neural Sciences, Cellular Signalling Unit, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0001-5545-9319
Christina HalseySchool of Cancer Sciences, University of Glasgow, Scotland, UK.ORCID 0000-0001-5449-5246
Shehab IsmailDepartment of Chemistry, KU Leuven, Heverlee, Belgium shehab.ismail.mohamed@kuleuven.be.ORCID 0000-0002-4150-1077
Edward W RobertsCRUK Scotland Institute, Glasgow, UK ed.roberts@glasgow.ac.uk.ORCID 0000-0002-8229-1715

Funding

Defining the function of Complex I truncating mutations in cancerR37CA276200 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Payam Gammage, Eduard Reznik · 2023 to 2026
$2.5M
NCI NIH HHS R37 CA276200
6 · The paper itself

Abstract

T-cell receptor recognition of cognate peptide-MHC leads to the formation of signalling domains and the immunological synapse. Because of the close membrane apposition, there is rapid exclusion of CD45, and therefore LCK activation. Much less is known about whether spatial regulation of the intracellular face dictates LCK activity and TCR signal transduction. Moreover, as LCK is a driver in T acute lymphocytic leukaemia, it is important to understand its regulation. Here, we demonstrate a direct role of the ciliary protein UNC119 in trafficking LCK to the immunological synapse. Inhibiting UNC119 reduces localisation of LCK without impairing LCK phosphorylation and reduces T-cell receptor signal transduction. Although important for initial LCK reorganisation, activated CD8

Indexed as

Adaptor Proteins, Signal TransducingPrecursor T-Cell Lymphoblastic Leukemia-LymphomaReceptors, Antigen, T-CellT-LymphocytesCD8-Positive T-LymphocytesCell ProliferationHumansImmunological SynapsesLymphocyte ActivationLymphocyte Specific Protein Tyrosine Kinase p56(lck)PhosphorylationSignal TransductionAdaptor Proteins, Signal TransducingLCK protein, humanLymphocyte Specific Protein Tyrosine Kinase p56(lck)Receptors, Antigen, T-Cell

Identifiers

PMID39814552
PMCPMC11735834

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.