Evidence map›Paper›PMID 39814550›Full record

ArticleLife science alliance2025

Transcription factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress.

Milad Soleimani, Mark Duchow, Ria Goyal, Alexander Somma, Tamer S Kaoud, Kevin N Dalby, Jeanne Kowalski, S Gail Eckhardt, Carla Van Den Berg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Milad SoleimaniInterdisciplinary Life Sciences Graduate Programs, The University of Texas at Austin, Austin, TX, USA.
Mark DuchowLivestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
Ria GoyalLivestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-4225-4709
Alexander SommaLivestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
Tamer S KaoudDivision of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA.
Kevin N DalbyInterdisciplinary Life Sciences Graduate Programs, The University of Texas at Austin, Austin, TX, USA.
Jeanne KowalskiLivestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0003-3458-3024
S Gail EckhardtInterdisciplinary Life Sciences Graduate Programs, The University of Texas at Austin, Austin, TX, USA.
Carla Van Den BergInterdisciplinary Life Sciences Graduate Programs, The University of Texas at Austin, Austin, TX, USA carla.vandenberg@austin.utexas.edu.ORCID 0000-0003-1156-7216

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer stem cells (CSCs) are difficult to therapeutically target, but continued efforts are critical given their contribution to tumor heterogeneity and treatment resistance in triple-negative breast cancer. CSC properties are influenced by metabolic stress, but specific mechanisms are lacking for effective drug intervention. Our previous work on TFEB suggested a key function in CSC metabolism. Indeed, TFEB knockdown (KD) inhibited mammosphere formation in vitro and tumor initiation/growth in vivo. These phenotypic effects were accompanied by a decline in CD44

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsNeoplastic Stem CellsStress, PhysiologicalTriple Negative Breast NeoplasmsAnimalsAutophagyCell Line, TumorCell ProliferationDeoxyglucoseDrug Resistance, NeoplasmEndoplasmic Reticulum Chaperone BiPFemaleGene Expression Regulation, NeoplasticGlycolysisHumansMiceBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsDeoxyglucoseEndoplasmic Reticulum Chaperone BiPHspa5 protein, mouseTFEB protein, human

Identifiers

PMID39814550
PMCPMC11735543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.