Evidence map›Paper›PMID 39814274›Full record

ArticleJournal of biomedical informatics2025

BiomedRAG: A retrieval augmented large language model for biomedicine.

Mingchen Li, Halil Kilicoglu, Hua Xu, Rui Zhang

Abstract read
In one paragraph

Article in Journal of biomedical informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. RARE: Retrieval-Augmented Reasoning Enhancement for Large Language Models.Proceedings of the conference. Association for Computational Linguistics. Meeting · 2025
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mingchen LiDivision of Computational Health Sciences, Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
Halil KilicogluSchool of Information Sciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
Hua XuDepartment of Biomedical Informatics and Data Science, School of Medicine, Yale University, New Haven, CT, USA.
Rui ZhangDivision of Computational Health Sciences, Department of Surgery, University of Minnesota, Minneapolis, MN, USA. Electronic address: ruizhang@umn.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Racial disparities in access to kidney transplantationR01DK115629 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI R. Adams Dudley, KIRSTEN L. JOHANSEN · 2018 to 2026
$4.5M
Detecting synergistic effects of pharmacological and non-pharmacological interventions for AD/ADRDR01AG078154 · NIA · UNIVERSITY OF MINNESOTA · PI HUA XU, RUI ZHANG · 2022 to 2026
$4.2M
A Translational Informatics Framework to Mine Efficacy and Safety of Dietary SupplementsR01AT009457 · NCCIH · UNIVERSITY OF MINNESOTA · PI RUI ZHANG · 2017 to 2026
$4.1M
COMBINI: connecting COmplementary Medicine evidence and BIological kNowledge to support Integrative HealthU01AT012871 · NCCIH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Halil Kilicoglu, Cui Tao · 2024 to 2026
$1.9M
SCH: A New Computational Framework for Learning from Imbalanced Biomedical DataR01CA287413 · NCI · UNIVERSITY OF MINNESOTA · PI CUI, YING, SUN, JU · 2023 to 2025
$1.2M
Mining minority enriched AllofUs data for innovative ethnic specific risk prediction modelingR21MD019134 · NIMHD · UNIVERSITY OF MINNESOTA · PI HOU, JUE, WANG, JINHUA · 2023 to 2024
$436k
NCATS NIH HHS UL1 TR001863NCCIH NIH HHS R01 AT009457NCCIH NIH HHS U01 AT012871NCI NIH HHS R01 CA287413NIA NIH HHS R01 AG078154NIDDK NIH HHS R01 DK115629NIMHD NIH HHS R21 MD019134
6 · The paper itself

Abstract

Retrieval-augmented generation (RAG) involves a solution by retrieving knowledge from an established database to enhance the performance of large language models (LLM). , these models retrieve information at the sentence or paragraph level, potentially introducing noise and affecting the generation quality. To address these issues, we propose a novel BiomedRAG framework that directly feeds automatically retrieved chunk-based documents into the LLM. Our evaluation of BiomedRAG across four biomedical natural language processing tasks using eight datasets demonstrates that our proposed framework not only improves the performance by 9.95% on average, but also achieves state-of-the-art results, surpassing various baselines by 4.97%. BiomedRAG paves the way for more accurate and adaptable LLM applications in the biomedical domain.

Indexed as

Data MiningInformation Storage and RetrievalMedical InformaticsNatural Language ProcessingAlgorithmsDatabases, FactualHumansLarge Language ModelsLarge language modelRetrieval-augmented generation

Identifiers

PMID39814274
PMCPMC11837810

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.