ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2026
Neurophysiological Markers of Regulation Success in Everyday Life in Depression.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Time in remission from depression predicts cognitive-affective regulation dynamics in everyday life.Journal of clinical and experimental neuropsychologyArticle
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Authors and funding
13 authors.
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Abstract
backgroundSelf-regulation is often disrupted in depression and is characterized by negative affect and inflexible parasympathetic responses. However, our understanding of brain mechanisms of self-regulatory processes has largely been limited to laboratory contexts. Measuring individual differences in self-regulatory processes in everyday life-and their neural correlates-could inform our understanding of depression phenotypes and reveal novel intervention targets that impact everyday functioning.
methodsIn individuals with remitted major depressive disorder and healthy comparison participants (N = 74), we measured 2 dimensions of regulation success in everyday life-perceived success with regulating affect and physiological success (parasympathetic augmentation following regulation attempts)-and their neural correlates using a functional magnetic resonance imaging emotion regulation task.
resultsPerceptions of success were weakly associated with physiological success and had partially distinct neural correlates. Perceived success and physiological success in everyday life predicted reduced activity in brain regions involved in emotional salience while reacting to aversive stimuli in the scanner. During reappraisal in the scanner, greater perceived success in everyday life was dimensionally associated with more reappraisal-related activity in regions involved in cognitive control (including the dorsolateral and dorsomedial prefrontal cortices); in contrast, physiological success predicted enhanced downregulation of salience network activity (amygdala, insula).
conclusionsResults suggest that linking psychophysiology with behavior in everyday life can provide a window into dissociable dimensions of self-regulatory functioning. Integrating ambulatory and brain-based metrics may elucidate self-regulatory phenotypes with distinct neurophysiological mechanisms and targets for intervention to impact functioning in daily life.
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